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Method for synthesizing conjugated linoleic acid using mixed solvent

A conjugated linoleic acid and mixed solvent technology, applied in chemical instruments and methods, preparation and application of organic compounds, etc., can solve the problems of high cost of solvent recovery, high cost of separation of solvent and by-product glycerol, large amount of solvent, etc.

Inactive Publication Date: 2003-07-16
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the amount of solvent used in the alkali isomerization process is large, which is two to five times that of the raw oil. The cost of solvent recovery in industrial production is high, and the cost of separating the solvent from the by-product --- glycerin is high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] a. Dissolve 25 kilograms of sodium hydroxide in a mixed solvent containing 50 kilograms of glycerin and 350 kilograms of propylene glycol, heat up to 90° C., stir simultaneously, and constantly feed nitrogen to replace the air therein;

[0024] b, 100 kilograms of safflower oil are added in the reactor, and the temperature is controlled at 170° C.;

[0025] c. After reacting for 4 hours, cool to about 80°C and neutralize with hydrochloric acid to pH 3;

[0026] d, the reaction liquid is extracted with non-polar solvent hexane, and the extract liquid oil phase (I) and the raffinate water phase (II) are separated with a stratifier;

[0027] e, the extract oil phase (I) is washed with hot water, brine, and deionized water three times, and the solvent is evaporated to obtain a mixed fatty acid containing 70-80% of conjugated linoleic acid;

[0028] f. The recovered solvent obtained after the raffinate aqueous phase (II) is vacuum dehydrated and filtered to desalt can conti...

Embodiment 2

[0030] a. Dissolve 10 kilograms of potassium hydroxide in a mixed solvent containing 50 kilograms of glycerin and 50 kilograms of ethylene glycol, heat up to 100° C. while stirring, and continuously feed nitrogen to replace the air therein;

[0031] B, 100 kilograms of sunflower oils are added in the reactor, and temperature is controlled at 100 ℃;

[0032] c. After reacting for 2 hours, cool to about 80°C and neutralize to pH 4 with sulfuric acid;

[0033] d, the reaction liquid is extracted with non-polar solvent hexane, and the extract liquid oil phase (I) and the raffinate water phase (II) are separated with a stratifier;

[0034] e, the extract oil phase (I) is washed with hot water, brine, and deionized water three times, and the solvent is evaporated to obtain a mixed fatty acid containing 30-40% of conjugated linoleic acid;

[0035] f. The recovered solvent obtained after the raffinate aqueous phase (II) is vacuum dehydrated and filtered to desalt can continue to be r...

Embodiment 3

[0037] a. Dissolve 20 kilograms of sodium methylate in a mixed solvent containing 40 kilograms of glycerin, 100 kilograms of propylene glycol and 160 kilograms of butanediol, heat up to 110° C., stir simultaneously, and constantly feed nitrogen to replace the air therein;

[0038] B, 100 kilograms of cottonseed oils are added in the reactor, and temperature is controlled at 100 ℃;

[0039] c. After reacting for 3 hours, cool to about 80°C and neutralize with phosphoric acid to pH 4;

[0040] d, the reaction liquid is extracted with non-polar solvent hexane, and the extract liquid oil phase (I) and the raffinate water phase (II) are separated with a stratifier;

[0041] e, the extract oil phase (I) is washed with hot water, brine, and deionized water three times, and the solvent is evaporated to obtain a mixed fatty acid containing 40-50% of conjugated linoleic acid;

[0042] f. The recovered solvent obtained after the raffinate aqueous phase (II) is vacuum dehydrated and filt...

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PUM

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Abstract

A process for synthesizing the conjugated linoleic acid from the oil with high content of linolenic acid features use of mixed solvent or the recovered solvent obtained by dewatering and desalting the substance separated from its product for alkali isomerization. Its advantages are simple operation and low cost.

Description

technical field [0001] The invention relates to a method for synthesizing conjugated linoleic acid using a mixed solvent Background technique [0002] Conjugated linoleic acid has attracted the attention of more and more domestic and foreign scientific research and medical institutions for its excellent health care and disease resistance functions, and they are competing to develop products in the food, medicine and feed industries. Conjugated linoleic acid can induce energy utilization and lead to weight loss without storing fat (US Patent 5,554,646; US Patent 5,814,663; World Patent PCT WO 97 / 46230), promotes the effective absorption of food (US Patent 5,428,072), and is eaten by athletes After that, it can slow down metabolism and enhance endurance (US Patent 5,919,767); it can alleviate the side effects of immune reactions such as anorexia and proteolysis (US Patent 5,430,066; US Patent 5,585,400); it has anti-mutation and protects humans and animal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/105A23K20/158A23K40/00A23L33/115A61K31/20C07C51/353C07C57/12
Inventor 吾满江・艾力文彬马莉樊莉张亚刚努尔・买买提孙庶冬杨晓冬刘远凤陶敏芳阿依夏木陈炜
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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