Chitosam chromium, its preparing method and application
A technology of chitosan and chromium ions, which is used in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., to achieve the effect of lowering blood sugar
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example 1
[0048] Example one (chitosan chromium nitrate) is equipped with stirrer, solid feeds intake, and liquid feeds inlet, and reaction liquid lower aeration port and reaction liquid go up aeration port, adds decrystallization in 100 liters of reaction tanks of bottom discharge port Chitosan (provided by Nantong Shuanglin Company) 2.00KG, add drinking purified water 45dm 3 . Use a nitrogen bottle to inflate and stir the reaction liquid for 20 minutes, and start the stirrer to stir. Another preparation of 769.23g chromium nitrate nonahydrate dissolved in 5dm 3 solution in water, and nitrogen gas for more than 20 minutes. In a nitrogen atmosphere, through the liquid feeding port, the chromium compound solution was added dropwise to the reaction tank in half an hour. Afterwards, heat up to 45 degrees with steam, and react under stirring for 6-7 hours. After cooling to below 35 degrees. Add 40 kilograms of ethanol in the tank, discharge after stirring. Adjust the pH value to 7-7.5...
example 2
[0049] ICP analysis of the complex showed a Cr content of 6.46% by weight. Infrared spectrum analysis (Fig. 1) shows that due to coordination with metal chromium ions, the peak type of the absorption peak reflecting the vibration of the sugar ring skeleton of glucosamine has changed. at 1384cm -1 、825cm -1 There is a characteristic absorption peak of nitro group. Carry out washing with EDTA, after removing part chromium, change to the peak type change of the chitosan of raw material (example 7: Figure 7 ). In the powdery solid reflectance visible ultraviolet spectrum ( Figure 2a ) in the absorption peak at 620nm, which is not characteristic of chitosan, which also indicates that a coordination compound is produced. Thermal analysis (Figure 3) shows that the thermal weight loss of the chitosan chromium complex and chitosan starts at 50°C, however, the corresponding dehydration of chitosan is completed before 100°C, while the weight loss of chitosan chromium is compared ...
example 4
[0054] The sample was analyzed by ICP, and the chromium content was 6.1% (percentage by weight). IR( Figure 5 ) there is no obvious nitro peak. It shows that the obtained complex is chitosan chromium hydrochloride in which the nitro group is replaced by chloride ion. Example 4 (Acetate of Chitosan)
[0055] Take 7 ml of chromium acetate aqueous solution (concentration 50%, density 1.26 g / ml), add water to 250 ml, stir evenly, add 5 g of chitosan sample after decrystallization and drying to the solution, and stir at 1°C for 46 hours . Take out 25 ml from the solution, add 50 ml of absolute ethanol, immediately a frozen green precipitate precipitates, centrifuge, and wash twice with absolute ethanol, the green is washed into light green, and the solid is dried under an infrared lamp A light green precipitate was obtained.
[0056] The sample was analyzed by ICP, and the chromium content was 5.12% (percentage by weight). IR( Figure 6 ) on 1605cm -1 Strong peaks exist. ...
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