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Alkaloid oral applied drop pills possessing anticarcinogenesis and its preparation method

A technology of alkaloids and dripping pills, applied in the directions of pill delivery, drug combination, antitumor drugs, etc., to achieve the effects of being conducive to stability, storage and transportation, improving solubility, and avoiding pain

Inactive Publication Date: 2003-12-24
刘智
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its advantages are: it can improve the solubility of alkaloids, so that the medicine can better exert its drug effect in the human body, it is convenient to take, the dosage is accurate, and it avoids the pain caused by the injection of the patient. Storage and transportation, at present, there is no oral drop pill made of anticancer alkaloid active drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 5g of camptothecin, add 20g of polyethylene glycol (6000) and 20g of polyethylene glycol (4000), mix, heat in a water bath to melt the mixture, stir evenly, put it in the dropping pill machine, at 120-140°C, Drop the molten liquid into the simethicone oil condensing agent at a rate of 80 drops per minute, and make 1000 spherical pellets after cooling, take out these pellets, wash the condensing agent with ethanol, take out the pellets and dry them with cold wind, After passing the inspection, the finished product is obtained.

Embodiment 2

[0015] Take 6g of paclitaxel, add 12g of polyethylene glycol (6000), 3g of sodium stearate, 6g of glycerin gelatin, mix, heat in a water bath to melt the mixture, stir evenly, put it in the dropping pill machine, at 130-150°C, with Drop the molten liquid into the liquid paraffin condensing agent at a speed of 60 drops per minute, and make 1000 spherical pellets after cooling, take out these pellets, wash the condensing agent with petroleum ether, take out the pellets and dry them with cold wind, and pass the inspection After that, the finished product is obtained.

Embodiment 3

[0017] Take 1g of homoharringtonine, add 10g of polyethylene glycol (6000), 5g of stearic acid, and 2g of insect wax, mix, heat in a water bath to melt the mixture, stir evenly, put it in a dripping pill machine, and heat it at 100-120°C Under normal conditions, drop the molten liquid into the camellia oil condensing agent at a rate of 100 drops per minute, and make 1000 spherical pellets after cooling, take out these pellets, wash the condensing agent with acetone, take out the pellets and dry them with cold wind, After passing the inspection, the finished product is obtained.

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PUM

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Abstract

An orally-applied dropping pill of anticancer alkaloid contains camptothecine or taxol or harringtonine or homoharringtonine and matrix of dropping pill. Its preparing process includes proportioning,thermal fusion, stirring, and dropping it at 60-150 deg.c in condensing agent at speed of 20-100 drops per min, and removing condensing agent.

Description

technical field [0001] The invention relates to a drop pill of medicine, in particular to an oral drop pill of alkaloid with anticancer effect and a preparation method thereof. Background technique [0002] Malignant tumor is a common and frequently-occurring disease that seriously threatens human health. Current tumor treatment methods include drug therapy, surgery and radiation therapy. Antineoplastic drugs refer to drugs against malignant tumors, also known as anticancer drugs. The alkaloids with anti-cancer effect extracted from plants are an important category of anti-cancer drugs, such as camptothecin extracted from Camptotheca japonica, paclitaxel extracted from the bark of Taxus brevifolia, and The harringtonine and homoharringtonine are extracted from the cloverleaf plant of the family Torreya. These alkaloid active drugs with anti-cancer effects can also be obtained by chemical synthesis technology. They are all extremely poor in water solubility, and currently ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/55A61P35/00
Inventor 刘智许军
Owner 刘智
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