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Method for recovering monosaccharide from solution using weakly acid cation exchange resin for chromatographic separation

A weak acid cation and cation exchange technology, which is applied to the application of weak acid cation exchange resins in multi-step processes in chromatographic columns, can solve the problem of low hydrophilicity, weak acid cation exchange resins are not recommended, and xylose and xylose cannot be fully separated. Xylonic acid and other issues

Inactive Publication Date: 2004-01-07
DANISCO SWEETENERS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with water is that the various monosaccharides such as rhamnose, xylose and arabinose have almost similar residence times, so the fractions will overlap
There is a problem of not adequately separating xylose and xylonic acid, and the use of weak acid cation exchange resins that might give the benefit of addressing this problem is not suggested
For example, H + The form of the resin appears to be stronger than Na + Forms of resin with low hydrophilicity

Method used

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  • Method for recovering monosaccharide from solution using weakly acid cation exchange resin for chromatographic separation
  • Method for recovering monosaccharide from solution using weakly acid cation exchange resin for chromatographic separation
  • Method for recovering monosaccharide from solution using weakly acid cation exchange resin for chromatographic separation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] with H + / Mg 2+ Form resin chromatographic separation of xylose crystallization effluent

[0046] The xylose crystallization effluent (a beechwood-based Mg-based si-cooking liquor) was subjected to chromatography. The separation is carried out in a batch process in a laboratory chromatographic column. The column with a diameter of 0.045m is made of acrylic weak acid cation exchange resin (Finex CA 12 GC) manufactured by Finex Oy (Finland). TM )filling. The resin is an ethyl acrylate based resin. The height of the resin bed is about 0.70 m. The degree of crosslinking of the resin was 6% by weight DVB, and the average particle size of the resin was 0.26 mm. Regenerate the resin to the main H + Form (94% equivalent) and part of Mg 2+ form (6% equiv), and place the feeder on top of the resin bed. The temperature of the column and feed solution and elution water was about 65°C. The flow rate in the column was adjusted to 4ml / min.

[0047] Chromatographic separatio...

Embodiment 2

[0058] L-rhamnose was purified by chromatographic separation.

[0059] Xylose precipitate crystallization (last effluent) mother liquor from si-digestion of birch wood base was used as starting material and chromatographed in a batch separation column.

[0060] The separation is carried out in a batch process in a pilot chromatographic separation column. The whole device is composed of a raw material tank, a raw material pump, a heat exchanger, a chromatographic separation column, a product container, a feed solution, and an input pipeline for eluting water, an outflow pipeline and a flow control device.

[0061] A column with a diameter of 0.225 m was packed with an acrylic weak acid cation exchange resin (manufactured by Finex Ltd, Finland); the height of the resin bed was about 5.2 m. The degree of crosslinking of the resin was 3% by weight DVB, and the average particle size of the resin was 0.34 mm. Regenerate the resin into sodium (Na + ) form, and place the feeding de...

Embodiment 3

[0078] Chromatographic separation of the xylose-pentose arabinose fraction from the separation of rhamnose

[0079] The pentose-containing xylose fraction from rhamnose separation prepared as in Example 2 was subjected to chromatographic separation. Separation was carried out in a batch process in a pilot chromatographic separation column. A column with a diameter of 0.225 m was used with a strong acid cation exchange resin (Finex CS 13 GC TM , Finex Oy, made in Finland) filling. The height of the resin bed was 5.0 m. The degree of crosslinking of the resin was 5.5% by weight DVB and the average particle size of the resin was about 0.4 mm. Resin is Ca 2+ form. Place the loading device on top of the resin bed. The temperature of the column, feed solution and elution water is about 65°C. The flow rate in the column was adjusted to 30 l / h. Check filtration (through a filter bag) was performed prior to isolation.

[0080] Chromatographic separation was performed as follow...

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Abstract

The present invention relates to a method for recovering a monosaccharide selected from the group consisting of rhamnose, arabinose, xylose and mixtures thereof from a solution containing the same by a multistep process using chromatographic separation comprising at least one step, where a weakly acid cation exchange resin is used for the chromatographic separation.

Description

field of invention [0001] The present invention relates to a process comprising a multi-step process for the recovery of rhamnose and optionally arabinose. The invention more particularly relates to the use of weak acid cation exchange resins in chromatographic columns in a multi-step process. Background of the invention [0002] US 2 684 331 discloses a method for the chromatographic separation of two or more substances from one another, the ionization constants of which differ considerably and at least one of which ionizes significantly in its dilute aqueous solution. However, this method has not been used to separate sugars. The examples of US 2 684 331 describe a process for the separation of salts from organic solvents, for example sodium oxide from formaldehyde. The method involves the use of ion exchange resins that have the same ions as the highly ionized solute. The ion exchange resin is a cation exchange resin having an acid form or an anion exchange resin havin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88B01D9/02B01D15/00B01D15/08B01J20/281B01J20/285B01J39/04B01J39/20B01J39/26C07G99/00C07H3/02C07H3/08C13B20/14C13B30/02C13B35/06C13K13/00G01N30/26G01N30/30G01N30/46G01N30/50G01N30/64G01N30/80G01N30/84
CPCB01J39/046C13K13/002C13K13/00B01J39/26C13B30/02C13B20/144B01J39/07
Inventor H·海基莱J·云帕伊宁V·库鲁拉V·拉万卡T·泰尔瓦拉N·梅于雷
Owner DANISCO SWEETENERS
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