Transplanting method for intrahepatic transplanting pancreatic islet cells through hepatic artery

A technology of islet cells and hepatic artery, applied in medical science, surgery, etc., can solve problems such as liver infarction, diabetes control effect is not very good, liver failure and other problems, and achieve the effect of less trauma

Inactive Publication Date: 2004-02-11
长沙惠霖干细胞工程有限公司
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Problems solved by technology

However, the methods and parts of transplantation such as skeletal muscle and kidney subcapsule are not very effective in controlling

Method used

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Embodiment Construction

[0006] There were 4 patients with type I diabetes, including 3 males and 1 female, aged 6, 31, 36, and 40 years old, respectively.

[0007] Examination: 4 patients had fasting blood glucose of 12-15mmol / L before transplantation and postprandial blood glucose of 21-33mmol / L, all of whom had multiple occurrences of ketosis and acidosis; the daily dosage of exogenous insulin was 30U, 25U, 43U respectively , 48U. In 4 patients, the nervous system, fundus examination, B-ultrasound, electrocardiogram and other examinations found no abnormalities in lens, retina, cardiovascular, nervous system, heart, liver and kidney function. Before and after transplantation, the CD4 / CD8 ratio of the patients was measured by immunohistochemical method to monitor whether immune rejection occurred.

[0008] Isolation, purification and culture of porcine islet cells: newborn pigs (crown-tail 20-22cm) anesthetized with sodium pentobarbital at 2-5 days old were anesthetized, and the pancreas was remove...

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Abstract

The transplanting method for intrahepatic transplanting pancreatic islet cells through hepatic artery adopting Seldinger technology includes puncturing via femoral artery, inserting conduit to right hepatic artery, radiography confirmation, slow injecting via the conduit separated and purified pig pancreatic islet cells in the amount of (4-8)E6. The said method is favorable to the survival of transplanted pancreatic islet cells, has less wound, and can make pancreatic islet cells perform its physiological function safely and effectively.

Description

technical field [0001] The invention relates to a transplantation method for intrahepatic islet cell transplantation by interventional radiation technique. Background technique [0002] Because type 1 diabetes is under the situation of injecting exogenous insulin, the control to blood sugar is imprecise, often inevitably leads to the generation of various complications. Islet cell transplantation is considered the definitive treatment. Islet transplantation can not only correct abnormal glucose metabolism in diabetic patients, but more importantly, prevent the occurrence and development of diabetic microangiopathy. However, at present, the transplantation methods with more islet cells include abdominal cavity, subrenal capsule, skeletal muscle, and spleen transplantation. However, the methods and sites of these transplants are not the most effective way for the kinetic diffusion of sugar and insulin, and the transplanted sites cannot achieve the desired effect. According ...

Claims

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Application Information

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IPC IPC(8): A61B17/00
Inventor 王维刘晟罗贤明莫朝晖叶斌
Owner 长沙惠霖干细胞工程有限公司
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