Sodium bialginate for injection and its preparation method

Abstract

The present invention is one kind of freeze dried polysaccharide sulphate for injection, and each 1000 ampules of the injection contains polysaccharide sulphate 25-200 g and excipient 25-200 g. The injection preparation is prepared through advanced low temperature freeze drying process, and is stable in the preserving period and ever suitable for clinical application. The present invention has the functions of lowering blood viscosity, resisting blood coagulation, lowering blood fat, improving micro circulation, etc. and is used in preventing and treating ischemic cardiac and cerebral vascular diseases and hyperlipemia.

Description

technical field

[0001] The invention relates to a freeze-dried sodium alginate diester for injection, which belongs to a pharmaceutical preparation. Background technique

[0002] Sodium alginate diester is synthesized with alginic acid as the basic raw material and introduced effective groups by chemical methods. It is an acidic polysaccharide drug. Sodium alginate diester has strong dispersing and emulsifying properties, and is not easily affected by external factors. Because of its anionic polyelectrolyte fiber structure, the charges along the chain are concentrated, and under the action of its electric repulsion, it can make cells rich in negative charges The surface increases mutual repulsion, so it can resist the adhesion between red blood cells and between red blood cells and blood vessel walls, and has the effect of improving the viscoelasticity of blood rheology. In addition, sodium alginate diester can inactivate thrombin, and has prostagl...