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High-purity grape seed extract tablet and preparation method thereof

A grape seed, high-purity technology, applied in food preparation, food ingredients as solubility improvers, anti-toxic agents, etc., can solve the problems of large amount of excipients, hard tablets, slow disintegration speed, etc., to achieve strong anti-aging ability, High bioavailability and good tablet stability

Active Publication Date: 2015-07-15
HEXI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent solves the problem that the grape seed extract is difficult to carry, the prepared grape seed tablet contains a large amount of excipients, the grape seed extract is unevenly dispersed, the content uniformity is poor, and the tablet is too hard and the disintegration speed is slow , not conducive to disintegration, affecting the efficacy of the tablet, slow onset, poor stability, and thus affecting the bioavailability of the tablet

Method used

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  • High-purity grape seed extract tablet and preparation method thereof
  • High-purity grape seed extract tablet and preparation method thereof
  • High-purity grape seed extract tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] raw material:

[0044]

[0045]

[0046] Method:

[0047] A) take by weighing the grape seed extract of recipe quantity and pulverize, pass through 100 mesh sieves, standby;

[0048] b) take by weighing the maltodextrin and xylitol anhydride monooleate of the recipe quantity, grind, add the grape seed extract of step a) while grinding and continue to grind, and the grind is obtained;

[0049] c) grinding the starch of the described weight portion, 55% of the microcrystalline cellulose of the described weight portion and the carrageenan of the described weight portion to obtain a secondary ground;

[0050] d) mixing the main grinding material and the auxiliary grinding material uniformly, and granulating to obtain coarse particles;

[0051] e) passing the coarse particles through a 100-mesh screen to obtain fine particles;

[0052] f) Mix the silicon dioxide, magnesium stearate and the remaining part of the microcrystalline cellulose with the fine particles in t...

Embodiment 2

[0054] raw material:

[0055]

[0056] Method:

[0057] A) take by weighing the grape seed extract of recipe quantity and pulverize, pass 80 mesh sieves, standby;

[0058] b) take by weighing the maltodextrin and xylitol anhydride monooleate of recipe quantity, grind, add step while grinding

[0059] The grape seed extract in step a) continues to be ground, and the ground is obtained;

[0060] C) the starch of described weight portion and mannitol, the sodium carboxymethyl starch of 68% described weight portion are ground, obtain secondary grinding thing;

[0061] d) mixing the main grinding material and the auxiliary grinding material uniformly, and granulating to obtain coarse particles;

[0062] e) passing the coarse particles through a 100-mesh screen to obtain fine particles;

[0063] f) Mixing the polyethylene glycol 400 in the weight portion and the remaining part of sodium carboxymethyl starch with the fine granules uniformly, and tableting, to obtain the high-p...

Embodiment 3

[0065] raw material:

[0066]

[0067] Method:

[0068] A) take by weighing the grape seed extract of recipe quantity and pulverize, pass through 100 mesh sieves, standby;

[0069]b) take by weighing the maltodextrin of the recipe quantity, grind, add the grape seed extract of step a) while grinding and continue to grind, and the grind is obtained;

[0070] c) grinding the starch of the described weight portion and 65% of the microcrystalline cellulose of the described weight portion to obtain a secondary ground;

[0071] d) mixing the main grinding material and the auxiliary grinding material uniformly, and granulating to obtain coarse particles;

[0072] e) passing the coarse particles through a 120-mesh screen to obtain fine particles;

[0073] f) Mix the silicon dioxide, magnesium stearate and the remaining part of the microcrystalline cellulose with the fine particles in the weight portion uniformly, and press into tablets to obtain the high-purity grape seed extrac...

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Abstract

The invention discloses a high-purity grape seed extract tablet which comprises the following components in parts by weight: 700-1100 parts of grape seed extract, 30-70 parts of maltodextrin, 2-18 parts of filler, 5-35 parts of disintegrating agent, and 5-35 parts of lubricant, wherein the filler is starch, or a combination of starch and one or more of lactose, mannitol, xylitol and sorbitol; the disintegrating agent is one or more of sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, povidone, and croscarmellose sodium; the lubricant is one or more of magnesium stearate, hydrogenated vegetable oil, a stearic acid, silica, superfine silica powder, polyethylene glycol 400, and magnesium dodecyl sulfate. The high-purity grape seed extract tablet disclosed by the invention is small in amount of auxiliary materials, the grape seed extract is uniformly dispersed, the tablet is good in disintegration property and becomes effective slowly, and the tablet is good in stability, high in bioavailability, and strong in anti-aging ability.

Description

technical field [0001] The invention belongs to the field of health-care products with active ingredients of natural products, and particularly relates to a high-purity grape seed extract tablet prepared by using grape seed extract as a raw material and a preparation method thereof. technical background [0002] With the improvement of living standards, people pay more and more attention to their own health and appearance, and free radicals are intermediate metabolites produced by biochemical reactions of human tissues that damage physical health and accelerate aging. If there is too much, it needs to be suppressed and removed, otherwise it will damage human health, not only will produce various diseases, but also accelerate the aging of the body. Studies have shown that grape seed extract has super antioxidant capacity, which is 50 times that of vitamin E and 20 times that of vitamin C. It can prevent arteriosclerosis and delay aging. It is known as a skin vitamin; among th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/29A61K36/87A61K9/20A61K47/36A61K47/34A61K47/38A61K47/04A61K47/12A61P39/06A23L33/00
CPCA23L33/10A23L33/105A23P10/28A23V2002/00A23V2200/302A23V2250/21166A23V2250/5114A23V2250/5118A23V2250/51084A23V2250/18A23V2250/161A23V2250/1628A23V2200/238A23V2200/20A23V2250/5036
Inventor 罗光宏杨生辉周文政张娇朱小琴
Owner HEXI UNIV
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