Degradable nanometer composite material for biological and medical use

A nanocomposite material and biomedical technology, applied in the field of degradable biomedical nanocomposite materials and its preparation, can solve the problems of X-ray non-development, aseptic inflammatory reaction, large calcium phosphate particle size, etc., and meet the preparation process conditions Easy to implement, simple preparation process conditions, and easy industrialization

Inactive Publication Date: 2004-03-31
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of degradable material also has many shortcomings: after the material is implanted in the body, X-rays do not develop, and the implantation cannot be effectively detected; as the degradation time increases, the mechanical properties of this type of material decrease too quickly; during the degradation process Acidic substances produced in the
However, there are still differences between the structure of these composite materials and the structure of bone tissue: the main reason is that the particle size of calcium phosphate is relatively large (the calcium phosphate in bones is tens of nanometers, while their calcium phosphate is 1-100 μm). The degradation performance of the material is not good enough, and the dispersion of inorganic substances in the polymer matrix is ​​not uniform enough
The above invention cannot effectively adjust the degradation rate of the composite material to meet the requirements of different implantation sites for the degradation rate of the implant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Add 0.4g of apatite / β-phase tricalcium phosphate composite powder into 200ml of tetrahydrofuran, ultrasonically oscillate for 15 minutes, add 3.6g of polylactic acid, dissolve it under magnetic stirring at 50°C, ultrasonicate it, and cast it on a 38mm-diameter Form a film in the mold, after drying at 40°C for 24 hours, put it into a vacuum drying oven and dry it under vacuum until the quality of the film is constant. The calcium / PLA composite was refrigerated in a desiccator.

Embodiment 2

[0041] Add 0.2g of α-phase tricalcium phosphate powder into 200ml of dimethylformamide, ultrasonically oscillate for 15 minutes, then add 3.8g of polycaprolactone, dissolve it under magnetic stirring at 50°C, ultrasonicate it, and cast it on a 38mm-diameter Form a film in a mold, dry it at 160°C for 24 hours, then put it into a vacuum drying oven and dry it under vacuum until the quality of the film is constant. The fat composite material was placed in a desiccator and refrigerated.

Embodiment 3

[0043] Add 0.8g of α-phase tricalcium phosphate composite powder / β-phase tricalcium phosphate composite powder into 200ml of dimethyl sulfoxide, ultrasonically oscillate for 15 minutes, then add 3.2g of polylactic acid, magnetically stir and dissolve at 50°C and then ultrasonically After treatment, cast it into a mold with a diameter of 38mm to form a film. After drying at 160°C for 24 hours, put it in a vacuum drying oven and dry it in vacuum until the quality of the film is constant. The obtained α-phase tricalcium phosphate composite powder / β The calcium phosphate / polylactic acid composite material with a tricalcium phosphate composite powder content of 20 wt% is placed in a desiccator for refrigeration.

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PUM

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Abstract

A nanometer-grade medical decomposable composite material and its preparation method. By different Ca/P, different crystallizing states in the inorganic phase, the composite material adjusts decomposing rate, recombines with decomposable polymer, thus the biological decomoposing rate of the whole composite material is adjustable. The inorganic phase is selected from one or two of amorphous calcium phosphate, ª‡- tricalcium phosphate, ª‰- tricalcium phosphate, phosphorite and calcium phosphate dibasic. The preparation method comprises selecting organic solvents for uniformly dispersing calciumphosphate powder in a decomposable polymer matrix, then obtaining nanometer-grade composite material.

Description

technical field [0001] The invention relates to a degradable biomedical nanocomposite material and a preparation method thereof, belonging to the technical field of preparation of biomedical substitute materials. Background technique [0002] Due to diseases or trauma, hard tissues such as human bones or teeth are damaged or lost, and a large number of artificial synthetic substitute materials are needed for repair and treatment. At present, hard tissue replacement materials mainly include three types of materials: metals, ceramics, and polymers. They each have their own characteristics. [0003] Metal materials have high strength and are easy to process. However, the price is expensive, and it does not match the bone stress, which will cause bone tissue resorption, and the metal ions produced by physiological corrosion will have adverse reactions to the tissue, and such materials need a second operation to remove after the tissue heals. [0004...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56
Inventor 翁文剑李延报韩高荣杜丕一程逵沈鸽赵高凌张溪文
Owner ZHEJIANG UNIV
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