Active fragment of thymosin alphal and its polyethylene glycol derivatives

A technology of derivatives and peptide derivatives, applied in the field of law, can solve the problems of large dosage, long cycle and high price
CN1532206AInactive Publication Date: 2004-09-29INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
0 Cites 6 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Publication Date
2004-09-29
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention relates to active fragment of natural or artificial amino acid substituted thymosin alpha-1 and its polyethylene glycol derivatives, their preparation process, the medicine composition containing them, and their application in the medicine for preventing and treating diseases related with immune deficiency and hypoimmunity, including hepatitis B, hepatitis C, malignant melanoma, non-small cell lung carcinoma, SARS, etc.
Need to check novelty before this filing date? Find Prior Art

Description

field of invention

[0001] The present invention relates to thymosin alpha substituted with natural or unnatural amino acids 1 Active fragments and their PEGylated derivatives, their preparation methods, their pharmaceutical compositions and their use in medicines for the treatment or prevention of diseases related to immunodeficiency and immunodeficiency, including hepatitis B, C Applications in the treatment or prevention of hepatitis, malignant melanoma, non-small cell lung cancer, SARS (severe acute respiratory syndrome) and other related diseases caused by coronavirus. Background technique

[0002] thymosin alpha 1 (Tα 1 ) is an important polypeptide secreted by the thymus. It is an immune enhancer for T lymphocytes, which can promote the maturation and differentiation of T cells, and promote the secretion of various lymphokines (such as interleukin-2 and γ - interferon, etc.), can also promote the generation of interleukin-2 receptor. Tα 1 It consists of 28 amino a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More