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Method for extracting high purity seabuckthorn flavone aglycone

A technology of seabuckthorn flavonoids and an extraction method is applied in the field of high-purity preparation of flavonoid ligands, can solve problems such as no literature disclosure, and achieve the effects of easy industrial production, simple process and low cost

Active Publication Date: 2004-11-17
水利部沙棘开发管理中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that people have made many developments on seabuckthorn, such as seabuckthorn drink, seabuckthorn cosmetic, seabuckthorn beer, seabuckthorn tea, seabuckthorn soy sauce, seabuckthorn vinegar, seabuckthorn bean, seabuckthorn medical stone, seabuckthorn bodybuilding belt, seabuckthorn essence, seabuckthorn flavonoids Oral liquids, etc., there are also reports and patents on the combined process of extracting seabuckthorn flavonoids from seabuckthorn leaves through macroporous resins, and extracting seabuckthorn oil and seabuckthorn flavonoids from pulp, peel and leaves, but the extraction of high-purity seabuckthorn leaves using seabuckthorn leaves as raw materials The method of flavone ligand has not yet been published in the literature

Method used

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  • Method for extracting high purity seabuckthorn flavone aglycone
  • Method for extracting high purity seabuckthorn flavone aglycone
  • Method for extracting high purity seabuckthorn flavone aglycone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] In this example, 40-50 mesh seabuckthorn leaf powder is used as raw material to extract seabuckthorn flavonoids, and the process steps are as follows:

[0030] (1) Leaching

[0031] Weigh 1 kg of seabuckthorn leaf powder of 40 to 50 meshes, extract with 6 kg of methanol for 180 minutes at a temperature of 30°C, extract the extract, and then extract the second, 3 kg, and 3 kg of methanol respectively. For the third and fourth times, the extraction time was 120 minutes, and the extraction temperature was constant.

[0032] (2) Mixing and concentration of extract

[0033] The extracts obtained from the four extractions were mixed, and then subjected to vacuum distillation to recover the extractant. The temperature was controlled at 45°C and the pressure did not exceed -0.08MPa, and the extract was concentrated to 30% of its original volume.

[0034] (3) Extraction

[0035] The extraction is carried out at room temperature (about 20°C), using static extraction, the extra...

Embodiment 2

[0041] In this example, 50-60 mesh seabuckthorn leaf powder is used as raw material to extract seabuckthorn flavonoids, and the process steps are as follows:

[0042] (1) Leaching

[0043] Weigh 1 kg of seabuckthorn leaf powder of 50-60 meshes, extract with 15 kg of 30% ethanol-water mixture for 40 minutes at a temperature of 90°C, and extract the extract. The second and third extraction times were 30 minutes respectively, the fourth and fifth extraction times were 20 minutes respectively, the second to fifth extraction temperatures were 90°C and the extraction agent was the same as the first extraction time. times the same.

[0044] (2) Mixing and concentration of extract

[0045] The extracts obtained from the five extractions were mixed, and then subjected to vacuum distillation to recover the extractant. The temperature was controlled at 45°C and the pressure did not exceed -0.08MPa, and the extract was concentrated to 30% of its original volume.

[0046] (3) Extraction...

Embodiment 3

[0053] In this example, 40-60 mesh seabuckthorn leaf powder is used as raw material to extract seabuckthorn flavonoids, and the process steps are as follows:

[0054] (1) Leaching

[0055] Weigh 1 kg of 40-60 mesh seabuckthorn leaf powder, extract with 12 kg of 50% methanol-water mixture for 100 minutes at a temperature of 50°C, and extract the extract. For the second to fourth times, 10 kg, 8 kg, and 8 kg of 50% methanol-water mixture were used for extraction for 80 minutes each time, and the extraction temperature was 50° C.

[0056] (2) Mixing and concentration of extract

[0057]The extracts obtained from the four extractions were mixed, and then subjected to vacuum distillation to recover the extractant. The temperature was controlled at 35° C. and the pressure did not exceed -0.08 MPa, and the extract was concentrated to 30% of its original volume.

[0058] (3) Extraction

[0059] The extraction is carried out at room temperature (about 10°C), using dynamic extraction...

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Abstract

The invention discloses a method for extracting high purity seabuckthorn flavone aglycone by using seabuckthorn leaves as raw material through the steps of leaching, leach mixing, concentrating, extraction, hydrolyzing, edulcoration and dehydration, wherein the extraction agent is methanol or ethanol or the mixed liquid of methanol-water or ethanol-water, the extracting agent is cyclohexane or petroleum ether, the hydrolysate is 1-15% aqueous solution of hydrochloric acid or sulfuric acid or acetic acid or phosphoric acid.

Description

technical field [0001] The invention belongs to a high-purity preparation method of flavonoid alkaloids, in particular to a method for extracting flavonoid alkaloids from seabuckthorn leaves as raw materials. Background technique [0002] Flavonoids (Flavonoids) are mainly phytochemical components, widely present in the organs of various plants. Flavonoids in seabuckthorn are important biologically active substances, especially the flavonoids composed of quercetin, kaempferol and isorhamnetin in seabuckthorn leaves have outstanding medical properties, including antioxidant activity, enzyme inhibition, anti Cardiovascular and cerebrovascular diseases, anti-inflammatory activity, etc. are extremely important to human health, but the concentration of such flavonoids in seabuckthorn leaves is low, usually less than 1%, so they must be enriched to become useful products. It is known that people have made many developments on seabuckthorn, such as se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30
Inventor 邰源临李瑞霞杜宗良李海李永海温中平吴大诚
Owner 水利部沙棘开发管理中心
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