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Capsule agent containing L-glutamine and azulene sodium solfonate

A technology of glutamine and sodium azulene sulfonate, applied in the directions of capsule delivery, anti-inflammatory agent, non-central analgesic, etc., can solve the problems of inconvenient taking of granules, inaccurate dosage, easy spillage of medicaments, etc. To achieve the effect of accurate dose, not easy to lose, and easy to use

Inactive Publication Date: 2005-01-12
张红军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparations containing L-glutamine and sodium azulene sulfonate are only granules, and granules are inconvenient to take, and the medicine is easy to spill when taking it, resulting in the problem of inaccurate dosage and affecting the curative effect

Method used

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  • Capsule agent containing L-glutamine and azulene sodium solfonate

Examples

Experimental program
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Effect test

Embodiment 1

[0007] Take 495g of L-glutamine, 1.5g of sodium azulene sulfonate, and 3.5g of sodium carboxymethyl starch, mix them evenly by using the equal release method, pass through a 120-mesh sieve twice, and fill them into hard capsules to make 1000 cases Capsules of the present invention. Each hard capsule contains 495mg of L-glutamine and 1.5mg of sodium azulene sulfonate.

Embodiment 2

[0009] Get 663.3g of L-glutamine, 2.01g of sodium azulene sulfonate, and 4.69g of polyvinylpyrrolidone. First mix L-glutamine and sodium azulene sulfonate uniformly by equal release method, pass through a 120 mesh sieve twice, and set aside; prepare polyvinylpyrrolidone into 5% ethanol solution, set aside; mix 5% polyvinylpyrrolidone The vinylpyrrolidone ethanol solution is added to the mixed L-glutamine and sodium azulene sulfonate mixture, mixed, granulated, and filled into hard capsules after the granules are dried to make 1000 capsules of the present invention. Each hard capsule contains 663.3mg of L-glutamine and 2.01mg of sodium azulene sulfonate.

Embodiment 3

[0011] Take 50 g of L-glutamine, 5 g of sodium azulene sulfonate, and measure 150 g of polyethylene glycol 400. First mix L-glutamine and sodium azulene sulfonate with 50g polyethylene glycol 400, pulverize with a colloid mill, then add the remaining amount of polyethylene glycol 400 for miscibility, and prepare a solution; add gelatin solution (gelatin: Glycerol: water=10: 5.5: 12) for subsequent use; medicinal liquid and gelatin solution are obtained 1000 capsules of the present invention's soft capsules with a braking rotary encapsulation mechanism. Each hard capsule contains 50mg of L-glutamine and 5mg of sodium azulene sulfonate.

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Abstract

A capsule containing L-glutamine (C5H10N2O3) and sodium azulenylsulfonate (C15H17NaO3S.1 / 2H2O) is disclosed.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a capsule containing L-glutamine and sodium azulenesulfonate. Background technique [0002] Sodium azulene sulfonate (water-soluble azulene) can inhibit inflammation caused by various inflammatory substances, and the effect is relatively long-lasting; it can inhibit the release of histamine from inflammatory cells through local direct action; increase the synthesis of prostaglandin E2 in the mucosa, promote the formation of granulation and Epithelial neogenesis; reduces pepsin activity. L-glutamine (L-glutamine) can increase the biosynthesis of glucosamine, hexosamine, mucin and promote the regeneration of ulcer tissue. The joint application of the two is beneficial to the regeneration and repair of ulcer tissue and the formation of protective factors. Its advantages are good curative effect and low side effects. At present, the preparations containing L-glutamine and sodium azu...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/255A61P29/00
Inventor 张红军
Owner 张红军
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