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Total matrine and use of its preparation in zoopharmacy

A technology of total alkaloids of matrine and veterinary drugs, which is applied in the field of application of total alkaloids of matrine and its preparations in veterinary drugs, which can solve the problems of long drug production cycle, difficult production process control, and difficult removal of impurities, so that drug resistance is not easy to occur , Prolonged stability, improved purity

Inactive Publication Date: 2005-02-16
LUZHOU ECOLOGICAL SCI TECH SHANDONG
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Judging from the content disclosed in the patent document, the production cycle of the drug is too long, the production process may be difficult to control, the impurities in the drug ingredients are difficult to remove, and the stability of the drug is poor, and the storage time is too short. Its storage conditions may be relatively complex
In addition, this patent application only uses the fruit of Sophora sophora as a raw material, which limits its application and causes a waste of resources.

Method used

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  • Total matrine and use of its preparation in zoopharmacy

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Embodiment Construction

[0012] The present invention is explained in detail below:

[0013] The preparation method of the present invention: pulverize the dried roots or stems or seeds of the leguminous plant Sophora flavescens into coarse powder (generally crush to tens of meshes), soak the coarse powder in 98% ethanol at room temperature for 18 hours, and then After filtering, the filtrate was distilled under reduced pressure to recover ethanol. The residue was adjusted to pH 3-4 with 2% HCl. After washing twice with ether, the pH was adjusted to 7 with 5% sodium carbonate, and then extracted with chloroform. The extract was distilled to recover the chloroform. The residue is recrystallized with 98% ethanol, the crystal is dried to obtain a finished product, and then the finished product is sterilized and packed for use.

[0014] When the finished crystal of the present invention is used as a veterinary drug, it can be dissolved in water as an intramuscular injection, or it can be made into powder for ...

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Abstract

The invention relates to application of matridine in curing flow and animals' bacteria infection, the matridine is extracted from the soybean plants.

Description

Technical field [0001] The invention relates to the application of a total alkaloid extracted from plants in a medicine for treating bacterial infections of poultry and livestock. Background technique [0002] The modern aquaculture industry is increasingly becoming large-scale and intensive. In order to prevent and treat diseases caused by bacterial infections in concentrated-raised livestock, it is common practice at this stage to use a large number of antibiotics or other synthetic antibacterial drugs in livestock feed. For example: Chinese invention patent 99111531.7 discloses a kind of veterinary medicine suitable for epidemic diseases of poultry and livestock, which is to use drugs containing broad-spectrum antibiotics and antiviral, which are combined in a certain proportion to produce comprehensive antibacterial, anti-inflammatory and antiviral effects. It is used for the treatment of poultry and livestock with mixed infection of bacteria and viruses. However, due to the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K31/4375A61P31/04
Inventor 陆树林梁剑平苏建华
Owner LUZHOU ECOLOGICAL SCI TECH SHANDONG
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