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Prescription for liquid status of fluconazole and its preparation

A fluconazole and liquid type technology, applied in the field of fluconazole liquid type formulations and preparations thereof, can solve the problems of poor water solubility, large fluctuation of in vitro dissolution of tablets and hard capsules, and unfavorable clinical treatment, etc. Fast absorption and good taste

Inactive Publication Date: 2005-03-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing dosage forms of fluconazole are tablets, hard capsules, injections, etc. For oral solid preparations, due to the poor water solubility of fluconazole, the in vitro dissolution of tablets and hard capsules fluctuates greatly, depending on the manufacturer. And different (Gong Lingzhi etc., the determination of content and dissolution rate of fluconazole different dosage forms of four manufacturers Chinese Journal of Pharmaceutical Sciences, 2000, 35 (5): 340~341; The dissolution rate investigation of fluconazole capsules such as Yang Chunxiu Pediatric Pharmaceutical Journal 2001, 7(3): 8~9; Yan Jianming, Fluconazole Capsules Dissolution Test Data Processing Methods Comparative Pharmacology Progress, 1999, 23(2): 117~120; Yuan Jing, Dissolution Investigation of Fluconazole Capsules in Vitro Jiangsu Pharmacy and Clinical Research, 1999, 7(3):54~55), so unfavorable for clinical treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Component Weight (mg)

[0011] Fluconazole 50

[0012] soybean oil 250

[0013] Preparation Process:

[0014] Weigh the prescribed amount of fluconazole (crushed through a 300-mesh sieve) and soybean oil, place them in a batching tank, stir and mix them evenly, and go through the colloid grinding cycle for 5 times to obtain the fluconazole liquid. The obtained liquid can be prepared into soft capsules, liquid hard capsules and drops.

Embodiment 2

[0016] Component Weight (mg)

[0017] Fluconazole 50

[0018] soybean oil 150

[0019] Span 80 10

[0020] Alpha-tocopherol 1

[0021] Preparation Process:

[0022] Weigh the prescribed amount of Span 80, α-tocopherol and soybean oil, put them in the batching tank, mix well and dissolve, add fluconazole (crushed through a 200-mesh sieve), stir and mix well, and pass through the colloid grinding cycle for 5 times After that, fluconazole liquid is obtained. The obtained liquid can be prepared into soft capsules, liquid hard capsules and drops.

Embodiment 3

[0024] Component Weight (mg)

[0025] Fluconazole 50

[0026] Peanut Oil 200

[0027] beeswax 5

[0028] Dibutylhydroxytoluene 1

[0029] Preparation Process:

[0030] Weigh the prescribed amount of beeswax, dibutyl hydroxytoluene and peanut oil, put them in the batching tank, mix well, heat and dissolve, add fluconazole (crushed through a 200 mesh sieve), stir and mix well, and pass through the colloid grinding cycle for 3 times That is fluconazole liquid. The obtained liquid can be prepared into soft capsules, liquid hard capsules and drops.

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PUM

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Abstract

Disclosed is a prescription for liquid status of fluconazole and its preparation, wherein the prescription comprises Fluconazole and medicinal findings, the medicinal findings include diluent (orsolvent), anti-oxidant agent and suspension auxiliary agent, the diluent (orsolvent) includes two types of oil-soluble and water-soluble. The liquid form Fluconazole prepared by the two types of diluent (orsolvent) can be prepared into the dosage forms of capsule, liquid type hard capsule and drop pill.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a liquid formula of fluconazole and its preparation. Background technique: [0002] Fluconazole, its chemical name is: α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4 -Triazol-1-yl ethanol belongs to imidazole antifungal drugs, and its antifungal spectrum is relatively broad. Oral or intravenous injection of this product is effective for human and various animal fungal infections, such as Candida infection (including systemic candidiasis in immune normal or immune-compromised humans and animals), Cryptococcus neoformans infection (including intracranial infection), Malassezia furfur, Microsporum sp., Trichophyton sp., Epidermophyton sp., Blastomyces dermatitidis, Coccidioides immogenoides (including intracranial infections) and Histoplasma capsulatus, Chromobacter fischeri Cladosporium etc. are effective. The antibacterial activity of this product in vitro is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/48A61K31/4196A61P31/10
Inventor 邓意辉吴琼
Owner SHENYANG PHARMA UNIVERSITY
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