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Optical surface plasma wave nucleic acid sensor system for detecting mononucleotide polymorphism and detecting method

A surface plasmon, single nucleotide polymorphism technology, applied in the measurement of color/spectral characteristics, etc., can solve the problems of large sensing part, SPR signal is susceptible to mechanical structure, light source fluctuation, etc., to achieve high resolution, The effect of overcoming the instability of the light source and improving the measurement accuracy

Inactive Publication Date: 2005-03-23
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Problems solved by technology

[0009] With the continuous deepening of research work, the Kretschmann model based on prism coupling also shows the shortcomings of the large sensing part, which is not suitable for remote telemetry occasions and the SPR signal is easily affected by external factors such as mechanical structure and light source fluctuations.

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  • Optical surface plasma wave nucleic acid sensor system for detecting mononucleotide polymorphism and detecting method
  • Optical surface plasma wave nucleic acid sensor system for detecting mononucleotide polymorphism and detecting method
  • Optical surface plasma wave nucleic acid sensor system for detecting mononucleotide polymorphism and detecting method

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Embodiment Construction

[0022] Depend on figure 1 It can be seen that the specific composition of the optical fiber surface plasmon wave nucleic acid sensor system for detecting single nucleotide polymorphisms in the present invention is that the broadband light source 1 (LG150 type broadband light source can be used) passes through the P-type polarizer 2 to filter out the S polarized light , only the P-polarized light is coupled into the Y-type fiber coupler 3 (such as figure 2 shown), propagates to the output end of the Y-type optical fiber coupler 3, then passes through the coupler joint 4, propagates to the terminal reflective optical fiber surface plasmon wave nucleic acid sensing probe 6 through the sensing fiber 5, and is connected with the The interaction of nucleic acid molecules in the sample produces the surface plasmon resonance effect, and after passing through the micro-mirror on the end face of the fiber core in the probe 6, reflected light is formed and enters the spectrometer 7 thro...

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Abstract

The invention relates to an optical fiber surface plasma wave nucleic acid sensor and method for detecting polymorphism of nucleotide. The system includes wideband lamp house, P type Polaroid, gamma type optical fiber coupler, coupler interface, sensing optical fiber, detector of terminal reflective optical fiber surface plasma wave resonance biology sensor, spectrum device and computer. The invention uses terminal reflective optical fiber surface plasma wave nucleic sensor detector and distributed optical fiber surface plasma wave nucleic sensor detector to realize the detection of polymorphism of nucleotide. Compared with spectrum detection method, the accurate value of resonance spectrum wavelength of the surface plasma wave can be acquired. The invention needs not to be signed, and it has no damage to the sample.

Description

Technical field: [0001] The invention relates to a novel fiber optic nucleic acid sensor system combining surface plasma wave resonance effect and fiber optic technology, which can be applied to human genome research single nucleotide polymorphism (SNP). Background technique: [0002] The surface plasmon resonance (hereinafter referred to as SPR) effect is a physical optical phenomenon that occurs at the interface between metal and dielectric, and it is very sensitive to the change of the refractive index of the dielectric attached to the metal surface. Biosensing technology based on this effect has been widely used in many biochemical research fields such as immunology and drug screening. [0003] With the completion of the precise sequence map of the human genome, the focus of human genome research has entered the post-genome era. One of its main contents is the establishment of deoxyribonucleic acid (deoxyribonucleic acid) represented by single nucleotide polymorphism (si...

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Application Information

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IPC IPC(8): G01N21/25G01N21/27
Inventor 梁大开齐名曾捷崔英霞汤林虞伟
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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