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Indirubin oral dripping pill and preparing process

A preparation process, the technology of red dripping pills, is applied in the direction of pill delivery, medical preparations containing active ingredients, organic active ingredients, etc. It can solve the problems that the effectiveness is not fully exerted, and achieve increased bioavailability, good stability, High potency effect

Inactive Publication Date: 2005-05-18
许军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no one that utilizes indirubin to make oral drops, and its effectiveness has not been brought into full play.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Prescription: Indirubin 25.0g

[0017] Polyethylene glycol 6000 15.0g

[0018] Macrogol 4000 25.0g

[0019] Poloxamer 0.5g

[0020] Made into 1000 capsules, each capsule contains 25.0mg of indirubin on average

[0021] Add 25.0g of indirubin to 15.0g of polyethylene glycol 6000, 25.0g of polyethylene glycol 4000 and 0.5g of poloxamer, after heating, melting and mixing, at 70°C-95°C, at a rate of 50 drops per minute Drop into the condensation of simethicone oil, take it out after forming, remove the condensing agent, check the amount of ingredients, and pack it to get the finished product. Every 1000 indirubin dripping pills contains 25.0g of indirubin.

[0022] The inspection method is: this product is a dark purple dripping pill. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, and using benzene-chloroform (1:1) as a mobile phase; the detection wavelength is 289...

Embodiment 2

[0025] Prescription: Indirubin 10.0g

[0026] Polyoxyethylene monostearate 18.0g

[0027] Sodium stearate 20.0g

[0028] Polyethylene glycol 6000 5.0g

[0029] Made into 1000 capsules, each capsule contains 10.0mg of indirubin on average

[0030] Add 10.0g of indirubin to 5.0g of polyethylene glycol 6000, 18.0g of polyoxyethylene monostearate, and 20.0g of sodium stearate. The speed of 100 drops per minute is dropped into the liquid paraffin condensate oil. After forming, take it out, remove the condensing agent, check the component amount, and pack it to obtain the finished product. Every 1000 indirubin dripping pills contains 10.0g of indirubin.

[0031] The inspection method is: this product is a dark purple dripping pill. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, and using benzene-chloroform (1:1) as a mobile phase; the detection wavelength is 289nm, and the ...

Embodiment 3

[0034] Prescription: Indirubin 5.0g

[0035] Polyoxyethylene monostearate 20.0g

[0036] Macrogol 4000 23.0g

[0037] Made into 1000 capsules, each capsule contains 5.0mg of indirubin on average

[0038] Add 5.0g of indirubin to 23.0g of polyethylene glycol 4000, 20.0g of polyoxyethylene monostearate, heat, melt and mix well, then drop at a rate of 20 drops per minute at 85°C-100°C Put it into the vegetable oil condensate oil, after forming, take it out, remove the condensing agent, check the component quantity, pass it, pack it, and get the finished product. Every 1000 indirubin dripping pills contains 5.0g of indirubin.

[0039] The inspection method is: this product is a dark purple dripping pill. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, and using benzene-chloroform (1:1) as a mobile phase; the detection wavelength is 289nm, and the number of theoretical plates is c...

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PUM

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Abstract

The indirubin dripping pill containing indirubin 1-12 mg and proper amount of dripping pill medium in each pill. The dripping pill medium is one or two of polyglycol-6000, polyglycol-4000, polyoxyethylene monostearate, sodium stearate, glycerin, gelatin, poloxamer, stearic acid, glycerin monostearate and insect wax. The preparation process of the indirubin dripping pill includes melting and mixing indirubin and dripping pill medium, dropping at 60-120 deg.c into condensating agent, and eliminating condensating agent. The condensating agent is one or two of dimethyl silicon oil, liquid paraffin, tea seed oil and rape seed oil. The indirubin dripping pill is dark red. The indirubin dripping pill is used in treating chronic granulocyte leukaemia, and has the features of less side effect, low dosage, high medicinal effect, no obvious inhibition on marrow of patient, etc.

Description

technical field [0001] The invention relates to an oral drop pill, in particular to an indirubin drop pill for clearing heat, cooling blood and detoxifying for chronic myeloid leukemia and a preparation method thereof. Background technique [0002] The chemical name of indirubin is 2,2'-biindoline-3,3'-dione. It is a new anti-tumor drug with a new structure discovered by Chinese medical scientists in the mid-1970s. It is a new anti-cancer drug with anti-leukemia activity isolated from Qingdai. It has no inhibitory effect on the human immune system. Because the compound has obvious inhibitory effect on chronic myeloid leukemia, and has the characteristics of reliable clinical curative effect, less toxic and side effects, no obvious inhibitory effect on bone marrow and the like. Therefore, indirubin dripping pills and preparation technology have been studied to further exert the efficacy of indirubin in treating chronic myelogenous leukemia. [0003] Indirubin dripping pills...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/404A61P35/00
Inventor 许军彭红
Owner 许军
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