Transduction peptide-humanized chloine acetylase fusion protein and its use

A technology of fusion protein and choline acetylation, applied in the direction of transferase, peptide/protein component, fusion polypeptide, etc., can solve the problems of no detection of anti-AchR antibody, decrease of ChAT expression and activity, high technical requirements, etc., and achieve low cost , simplified purification process, high energy effect
CN1648135AInactive Publication Date: 2005-08-03INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Publication Date
2005-08-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a kind of fused transduction peptide-humanized choline acetylase protein and nucleic acid molecule connecting the nucleotide sequence of the said fusion protein. The present invention also relates to expression vector containing said nucleotide molecule. The present invention also relates to the use of the fusion protein in preparing medicine for treating neurodegeneration disease, preventing Alzheimer's disease, promoting learning memory function and promoting intelligence growth. The medicine composition containing the said fusion protein may be applied through injection, sublingual taking, aspiration, etc.
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Description

field of invention

[0001] The invention relates to a transduction peptide-human choline acetyltransferase fusion protein and nucleic acid molecules containing the nucleotide sequence encoding the fusion protein. The present invention also relates to expression vectors containing the above nucleic acid molecules. The present invention also relates to the use of the fusion protein for preparing medicines for treating neurodegenerative diseases or preventing Alzheimer's disease, promoting learning and memory functions, and promoting intelligence. The present invention particularly relates to a pharmaceutical composition containing the fusion protein, which can be administered in various ways such as injection, sublingual administration, lung inhalation, nasal mucosa, anal plug or skin absorption. Background of the invention

[0002] The biosynthetic enzyme of acetylcholine (Ach)-choline acetyltransferase (choline acetyltransferase, ChAT, EC 2.3.1.6), is an important enzyme in ...

Claims

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