Doxy rhodol magnetic microglobule and its making method
A technology for docetaxel and a preparation method is applied in the field of docetaxel magnetic microspheres and the preparation thereof, which can solve the problems of influence of treatment effect, toxic and side effects, low drug concentration in the target area, etc., and achieves reduction of systemic toxic and side effects and good magnetic response. The effect of improving the killing efficiency
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[0018] Example 1: (1) 1-2 mg of nano ferromagnetic particles, α 1 -Acid glycoprotein 2-10mg, docetaxel 1-2mg add distilled water to make a 50-150ml mixture; (2) Stir the mixture at a temperature of 30-40°C and a speed of 2000 revolutions per minute while pressing the volume The ratio is mixed solution: oleic acid=1:2-3, add 30-40℃ oleic acid dropwise, and continue to stir at 2000 rpm for 30-60 minutes; (3) Press the stirred mixture into volume The ratio is mixed liquid: oleic acid=1:3-5 ratio quickly poured into 80-100 ℃ oleic acid, fixed for 10 minutes; (4) the fixed liquid was stirred to room temperature at a speed of 2000 rpm; (5) Let stand at room temperature until stratification, discard the supernatant, and the lower layer particles are docetaxel magnetic microspheres. Docetaxel magnetic microspheres and Tween-80 are mixed in a volume ratio of 3-10:1, and then dissolved in distilled water to obtain a docetaxel magnetic microsphere solution.
Example Embodiment
[0019] Example two, (1) 1mg of nano ferromagnetic particles, α 1 -Acid glycoprotein 2-10mg, docetaxel 1mg add distilled water to make a 50-150ml mixture; (2) Stir the mixture at a temperature of 30-40°C and a speed of 2000 revolutions per minute, while the volume ratio is Mixture: oleic acid=1:2-3, add 30-40℃ oleic acid dropwise, and continue to stir for 30-60 minutes at a speed of 2000 revolutions / min; (3) The volume ratio of the stirred mixture is The mixed solution: oleic acid=1:3-5 is quickly poured into oleic acid at 80-100°C and fixed for 10 minutes; (4) The fixed liquid is stirred to room temperature at a speed of 2000 revolutions per minute; (5) ) Let it stand at room temperature until it separates, discard the supernatant, and the lower layer particles are docetaxel magnetic microspheres. Docetaxel magnetic microspheres and Tween-80 are mixed in a volume ratio of 3-10:1, and then dissolved in distilled water to obtain a docetaxel magnetic microsphere solution.
Example Embodiment
[0020] Example three, (1) 1mg of nano ferromagnetic particles, α 1 -Acid glycoprotein 2mg, docetaxel 1mg add distilled water to make a 50-150ml mixture; (2) Stir the mixture at a temperature of 30-40°C and a speed of 2000 rpm, and at the same time make a mixture by volume :Oleic acid=1:2, add 30-40℃ oleic acid dropwise, and continue to stir for 30-60 minutes at a speed of 2000 rpm; (3) The mixed liquid after stirring is made into a mixture by volume ratio: The ratio of acid=1:3 is quickly poured into oleic acid at 80-100°C and fixed for 10 minutes; (4) Stir the fixed liquid to room temperature at a speed of 2000 revolutions per minute; (5) Let stand at room temperature To stratify, discard the supernatant, and the lower layer particles are docetaxel magnetic microspheres. Docetaxel magnetic microspheres and Tween-80 are mixed in a volume ratio of 5:1, and then dissolved in distilled water to obtain a docetaxel magnetic microsphere solution.
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