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Doxy rhodol magnetic microglobule and its making method

A technology for docetaxel and a preparation method is applied in the field of docetaxel magnetic microspheres and the preparation thereof, which can solve the problems of influence of treatment effect, toxic and side effects, low drug concentration in the target area, etc., and achieves reduction of systemic toxic and side effects and good magnetic response. The effect of improving the killing efficiency

Inactive Publication Date: 2005-08-10
徐玉清 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the relatively large dose and systemic distribution of systemic chemotherapy, the drug concentration in the target area is relatively low
Not only the therapeutic effect is affected, but also the systemic administration will produce great toxic and side effects, which will seriously affect the patient's quality of life and therapeutic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one, (1) nano ferromagnetic particle 1-2mg, α 1 - Add 2-10 mg of acid glycoprotein and 1-2 mg of docetaxel to distilled water to form a 50-150 ml mixed solution; (2) Stir the mixed solution at a temperature of 30-40 ° C and a speed of 2000 rpm, and simultaneously press the volume The ratio is mixed solution: oleic acid = 1: 2-3, add dropwise oleic acid at 30-40°C, and continue stirring at a speed of 2000 rpm for 30-60 minutes; (3) mix the mixed solution by volume The ratio is mixed liquid: oleic acid = 1:3-5 and quickly poured into oleic acid at 80-100°C, and fixed for 10 minutes; (4) stirring the fixed liquid to room temperature at a speed of 2000 rpm; (5) Stand at room temperature until the layers are separated, discard the supernatant, and the particles in the lower layer are docetaxel magnetic microspheres. The docetaxel magnetic microspheres are mixed with Tween-80 at a volume ratio of 3-10:1, and then dissolved in distilled water to obtain a docetaxel ...

Embodiment 2

[0019] Embodiment two, (1) nano ferromagnetic particles 1mg, α 1 -acid glycoprotein 2-10mg, docetaxel 1mg, add distilled water and be made into 50-150ml mixed liquor; Mixed solution: oleic acid=1: 2-3 ratio drops the oleic acid of 30-40 ℃, continue to stir 30-60 minutes with the speed of 2000 revs / min; (3) the mixed solution after stirring is by volume ratio Mixed liquid: the ratio of oleic acid=1: 3-5 is poured rapidly in the oleic acid of 80-100 ℃, fixes 10 minutes; (4) the liquid after fixing is stirred to room temperature with the speed of 2000 rev / mins; (5 ) at room temperature until the layers are separated, the supernatant is discarded, and the particles in the lower layer are docetaxel magnetic microspheres. The docetaxel magnetic microspheres are mixed with Tween-80 at a volume ratio of 3-10:1, and then dissolved in distilled water to obtain a docetaxel magnetic microsphere solution.

Embodiment 3

[0020] Embodiment three, (1) nano ferromagnetic particle 1mg, α 1 - 2 mg of acid glycoprotein, 1 mg of docetaxel are added with distilled water to form a 50-150 ml mixed solution; (2) Stir the mixed solution at a temperature of 30-40 ° C and a speed of 2000 rpm, and at the same time, the mixed solution is mixed according to the volume ratio : the ratio of oleic acid=1:2 is added dropwise the oleic acid of 30-40 ℃, continues to stir 30-60 minutes with the speed of 2000 revs / min; (3) mixed solution after stirring is mixed solution by volume: oil The ratio of acid=1:3 is quickly poured into oleic acid at 80-100°C, and fixed for 10 minutes; (4) the fixed liquid is stirred to room temperature at a speed of 2000 rpm; (5) left standing at room temperature When the layers are separated, the supernatant is discarded, and the particles in the lower layer are docetaxel magnetic microspheres. Docetaxel magnetic microspheres are mixed with Tween-80 at a volume ratio of 5:1, and then disso...

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PUM

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Abstract

A magnetic microphere of doxytaxol for preventing and treating tumor contains proportionaly magnetic Fe3O4 nanoparticles, alpha 1-acidic glucoprotein, doxytaxol and oleic acid. Its advantage is high target performance. Its preparing process is also disclosed.

Description

(1) Technical field [0001] The present invention relates to a drug mainly characterized by a special carrier, specifically an anti-tumor targeted therapy drug. (2) Background technology [0002] Docetaxel, whose trade name is Taxotere, is an effective new chemotherapeutic drug, which has a fairly clear therapeutic effect in the treatment of various solid tumors such as lung cancer, breast cancer, and ovarian cancer. . However, due to the relatively large dose and systemic distribution of systemic chemotherapy, the drug concentration in the target area is relatively low. Not only the therapeutic effect is affected, but also the systemic administration will produce very large toxic and side effects, which will seriously affect the patient's quality of life and therapeutic effect. (3) Contents of the invention [0003] The purpose of the present invention is to provide a docetaxel magnetic microsphere that can reduce the toxic and side effects of chemotherapy, improve the c...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/337A61K47/02A61K47/42A61P35/00
Inventor 徐玉清文雪梅
Owner 徐玉清
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