Inhibitors of inflammatory gene activity and cholesterol biosynthesis

A gene and inflammation technology, applied in the field of inhibitors of inflammatory gene activity and cholesterol biosynthesis
CN1675376AInactive Publication Date: 2005-09-28WYETH HOLDINGS CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WYETH HOLDINGS CORP
Publication Date
2005-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods of identifying agents effective as inhibitors of short heterodimer protein (SHP) and farnesoid X receptor (FXR) and promoters, cell lines and vectors used in said methods. Methods of preparing and using the agents effective as inhibitors of short heterodimer protein (SHP), including methods of using same to prevent and / or treat a condition associated with inflammatory gene activity and / or cholesterol biosynthesis in a subject. Agents effective as inhibitors of short heterodimer protein (SHP) and farnesoid X receptor (FXR) and compositions comprising same, including compositions effective in reducing inflammatory gene activity and / or cholesterol biosynthesis in a subject.
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Description

Background of the invention

[0001] The present invention relates to methods for identifying agents capable of effectively inhibiting inflammatory disease activity and / or cholesterol biosynthesis, as well as preparation and use of compositions containing the agents for the prevention and / or treatment of conditions associated with inflammatory disease activity and / or cholesterol biosynthesis Methods, such as atherosclerosis, inflammatory bowel disease, kidney disease, etc. The present invention relates to agents that are potent inhibitors of inflammatory gene activity and / or cholesterol biosynthesis. For example, the invention relates to inhibitors of nuclear receptors, such as short heterodimeric protein (SHP) and farnesoid X receptor (FXR). The present invention relates to compositions containing such inhibitors, including compositions effective for the prevention and / or treatment of diseases or conditions associated with inflammatory gene expression and / or cholesterol biosyn...

Claims

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