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Cold resistance compound rimantadine preparation

A technology of rimantadine and rimantadine hydrochloride, applied in antiviral agents, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of lack of special ingredients for preventing and treating type A influenza, and achieve prevention and treatment Effects of viral cold and relief of other symptoms

Inactive Publication Date: 2005-11-02
ZHEJIANG APELOA KANGYU PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Commonly used in the market are compound preparations composed of antiviral drugs amantadine and pseudoephedrine hydrochloride, paracetamol, chlorpheniramine, etc. Ganmaotong, Suxiaoshangfeng Capsules, Ganmaoqing, etc. These cold medicines lack special ingredients for the prevention and treatment of type A influenza, and most of them can only relieve cold symptoms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: common tablet

[0045] Riantadine Hydrochloride 100mg

[0046] Paracetamol 250mg

[0047] Pseudoephedrine HCl 30mg

[0048] Chlorpheniramine 3mg

[0049] Mix pseudoephedrine hydrochloride, rimantadine hydrochloride, paracetamol, chlorpheniramine and 500g medical starch with 1000 times the prescription amount, make soft material, make wet granules, dry at 80-100 degrees for 4 hours, add 50g magnesium stearate after cooling, 50g of pregelatinized starch is mixed, granulated, compressed into tablets, film-coated, and packaged to obtain 1000 tablets.

Embodiment 2

[0050] Embodiment 2: common capsule

[0051] Riantadine Hydrochloride 100mg

[0052] Paracetamol 250mg

[0053] Pseudoephedrine HCl 30mg

[0054] Chlorpheniramine 3mg

[0055] Mix pseudoephedrine hydrochloride, rimantadine hydrochloride, paracetamol, chlorpheniramine and 500g medical starch with 1000 times the prescription amount, make soft material, make wet granules, dry at 80-100 degrees for 4 hours, add 50g magnesium stearate after cooling, 50g of pregelatinized starch is mixed, granulated, packed into capsules, and packaged to obtain 1000 capsules.

Embodiment 3

[0056] Embodiment 3: oral liquid

[0057] Riantadine Hydrochloride 100mg

[0058] Paracetamol 250mg

[0059] Pseudoephedrine HCl 30mg

[0060] Chlorpheniramine 3mg

[0061] Mix pseudoephedrine hydrochloride, rimantadine hydrochloride, paracetamol, chlorpheniramine and 200g sucrose 1000 times the prescription amount, add cosolvent, preservative and water to 10000ml, mix well, fill into 10ml glass ampoules, sterilize and pack . Get 1000 bottles of oral liquid.

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PUM

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Abstract

The present invention relates to cold resisting compound rimantadine preparation. The preparation is composition containing rimantadine hydrochloride, acetaminophen, pseudoephedrine hydrochloride, chlorpheniramine and its pharmaceutically acceptable salt. The composition is used in treating and remitting cold.

Description

Technical field: [0001] The present invention relates to the pharmaceutical composition containing rimantadine hydrochloride, paracetamol (acetaminophen), pseudoephedrine hydrochloride and chlorpheniramine (chlorpheniramine maleate) and pharmaceutically acceptable salt thereof, and this composition is used for Relieves and treats cold symptoms. Background technique: [0002] Influenza (flu) is the first viral acute respiratory infectious disease to be monitored globally. Due to the variability of influenza virus antigens, it cannot be completely controlled at present. It not only seriously endangers human physical and mental health, but can even take human life. Since Hong Kong reported that H5N1 avian influenza can infect humans in 1997, it has been confirmed that birds play a role in the origin of influenza pandemic strains. Avian influenza, commonly known as bird flu, is a severe infectious disease of poultry caused by type A influenza virus. [0003] Influenza is gene...

Claims

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Application Information

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IPC IPC(8): A61K31/4402
Inventor 金一傅红兴葛萌芽汪成发张屹挺
Owner ZHEJIANG APELOA KANGYU PHARMA
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