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External-applied ointment used for treating thyropathy, and its prepn. method

An anti-thyroid, ointment technology, applied in the directions of ointment delivery, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve problems such as skin discomfort and affect application, and achieve the effect of reducing pain and improving effect

Active Publication Date: 2005-11-09
陈凌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been found clinically that many patients with hyperthyroidism have obvious skin side effects at the application site of the neck after applying this topical anti-thyroid cream, such as skin discomfort, burning sensation, skin tightening, itching, congestion, pimples and redness etc., resulting in some patients being forced to stop taking the drug, seriously affecting the application of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1-5

[0033] The raw material components and mass percentages of Examples 1-5 are shown in Table 2. The preparation process is as follows:

[0034] (1) adding ethanol to glucocorticoids to obtain a suspension; (2) putting preservatives and antioxidants into distilled water and mixing; (3) antithyroid drugs, water-soluble substrates and steps (1), ( 2) Mix and heat the suspension to 75±5°C, and mix to obtain the water phase; (4) Mix, heat, and mix the oily base to obtain the oil phase; (5) Mix the oil phase and the water phase, and heat to 80°C, add essence after cooling to obtain ointment.

[0035] Table 2.

[0036] Component content (mass%)

[0037] distilled water

example 6

[0039] This example is the treatment of several typical clinical cases:

[0040] (1) ××, female, 25 years old. Two months ago, due to hyperthyroidism, oral methimazole and propylthiouracil caused severe neutropenia and stopped using it. Since the hyperthyroidism was not controlled and no oral antithyroid drugs were available, the antithyroid cream preparation of the original invention was used for treatment. On the third day of application, flushing and itching appeared on the application site of the neck. On the seventh day, the local skin damage continued to aggravate, manifested as erythema, swelling, and unbearable itching. After 7 days of drug withdrawal, the above-mentioned skin lesions disappeared substantially. At this time, hyperthyroidism further aggravated. Then use antithyroid ointment new preparation treatment of the present invention instead. Three weeks after treatment, the thyroid function returned to normal and the symptoms of hyperthyroidism disappeared....

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Abstract

An exterior-applied ointment for treating thyroidism is prepared from glucocorticoid, thyroidism-resistant medicines, percutaneous promoter, oily matrix, water-soluble matrix, and distilled water.

Description

technical field [0001] The invention belongs to the field of antithyroid ointment drugs for external application. Background technique [0002] Hyperthyroidism is a common disease, frequently-occurring disease. Since the birth of thiourea and imidazole antithyroid drugs (hereinafter referred to as OATD) in 1942, OATD has been the main treatment for hyperthyroidism (hereinafter referred to as hyperthyroidism). Due to the pharmacological properties of OATD itself and the route of oral administration, it has the disadvantages of slow and unstable curative effect, low remission rate after drug withdrawal and some systemic side effects. Therefore, in 1993, Chen Ling et al. developed "anti-thyroid cream for external application" ", and applied for an invention patent, which has been authorized, and its patent number is ZL93111370.9 (hereinafter referred to as the original invention). The original invention discloses an oil-in-water cream containing antithyroid drugs and glucocor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/06A61K47/10A61K47/12A61K47/14A61K47/22A61K47/38
CPCA61K47/14A61K47/38A61K47/12A61K47/10A61K9/0014A61K47/22A61K45/06A61P5/16
Inventor 陈凌
Owner 陈凌
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