Macroporous brushite bone cement with latent hole forming agent and preparation process thereof
A porosity calcium phosphate rock and bone cement technology, applied in latent macroporous calcium phosphate rock bone cement and its preparation, in the field of biomedical bone materials, can solve the problems of poor plasticity, poor binding stability, slow HA degradation rate, etc. , to achieve good biocompatibility
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[0021] Example 1
[0022] The powder of β-tricalcium phosphate and monocalcium phosphate monohydrate salt is mixed at a ratio of 1.22:1 by mole to form a composite calcium phosphate salt powder, and then 1% by weight of dry powder is added to the composite powder. The rubber powder particles are evenly mixed and used as brushite bone cement powder. Then mix the above-mentioned bone cement powder with 0.2mol / L sodium pyrophosphate aqueous solution in a ratio of 2.7:1 by weight (P / L), and adjust it into a paste to make a Φ9mm×12mm sample. It was cured in an environment of 37°C and 100% humidity, and the average curing time was measured to be 7 minutes, and the average compressive strength reached 13.8 MPa.
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[0023] Example 2
[0024] Except that 8% by weight of dry gelatin powder is added to the composite calcium phosphate powder when preparing brushite bone cement powder, the rest of the preparation method and process refer to Example 1. The latent macroporous brushite bone cement obtained in this example has an average curing time of 16 minutes and an average compressive strength of 5.6 MPa, reaching the level of cancellous bone.
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[0025] Example 3
[0026] The composite calcium phosphate salt powder in Example 1 was directly mixed and solidified with the sodium pyrophosphate curing liquid, without adding latent pore-forming agent gelatin. In addition, the preparation method and process of calcium phosphate bone cement were referred to Example 1. The bone cement sample obtained in this example has an average curing time of 7 minutes and an average compressive strength of 15.1 MPa.
[0027] The in vivo simulation tests on the latent macroporous brushite bone cement prepared in the above examples are as follows:
[0028] The uniformly prepared brushite bone cement paste is poured into a 2ml plastic mold to prepare a sample of Φ9mm×12mm. Then place the sample in an environment of 37°C and 100% humidity, and measure the curing time after curing, and then put the cured body in a phosphate buffer (PBS, pH=7.4) at 37°C for 1 week. The gelatin dissolves to form a large open pore structure. Scanning electron microsco...
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