Total secondary ginseng glucoside medicine composition, its prepn. method and application in preparing medicine for treating myocardial ischemia and hemorrhagic shock
A technology of ginseng total glycosides and composition, which is applied in the direction of drug combination, cardiovascular system diseases, and pharmaceutical formulations. Effect
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Embodiment 1
[0081] Example 1: Effect on myocardial ischemia of coronary artery ligation in anesthetized dogs
[0082]The experimental dogs were divided into eight groups, each with 6: blank control group, normal saline 3ml / kg, Hexinshuang group, 5mg / kg, Diaoxinxuekang group, 200mg / kg, ginseng root total saponins group (abbreviated as root total saponins), 200mg / kg, total saponins of ginseng stems and leaves (abbreviated as total saponins of stems and leaves) 200mg / kg dose group, 25mg / kg total ginseng glycosides dose group, 50mg / kg total ginseng glycosides dose group, ginseng total saponins 100mg / kg dose group. The experimental drug was formulated into the same volume (3ml / kg) with distilled water, and was administered through the duodenum.
[0083] The animal was anesthetized with sodium pentobarbital (30mg / kg), handwritten, and the pericardial bed was made; the left circumflex branch of the coronary artery was separated, an electromagnetic flowmeter (MF-1100, Nihon Koko) probe was placed, an...
Embodiment 4
[0105] Example 4: Effect on rat heart failure model induced by sodium pentobarbital
[0106] Healthy SD rats, weighing 250-350g, 50 males. Randomly divided into 5 groups: control group (with equal volume of vehicle control), root total saponins group (200mg / Kg), ginseng total glycosides high, medium and low dose groups (200, 100, 50mg / Kg). Gavage was administered for 7 consecutive days, 10 rats in each group, and the administration volume was 5ml / kg.
[0107] After the rats were weighed, they were anesthetized with 3% pentobarbital sodium, fixed on the back, separated the right common carotid artery and the left femoral artery vein, made arterial cannulation, connected eight physiometer pressure sensors, and the venous cannula was waiting for the pentobarbital. Barbital sodium, connect the ECG port lead. Record the normal values of the following indicators: left ventricular systolic blood pressure (LVSP), arterial systolic blood pressure (SBP), arterial diastolic blood pressure ...
Embodiment 5
[0123] Example 5: Effect on dogs with hemorrhagic shock
[0124] Thirty-six healthy mongrel dogs, both male and female, were randomly divided into six groups: blank control group (equal volume of distilled water), Shenmai injection 10mg / Kg group, ginseng root total saponins (referred to as root total saponins) 200mg / Kg group, Ginseng total glycosides high-dose group, middle-dose group, low-dose group (200, 100, 50 mg / Kg). Pentobarbital (30mg / Kg) was injected intravenously for anesthesia, fixed on the back, endotracheal intubation, and adjustment of eight physiological recorders. The right femoral artery is cannulated, connected to a pressure converter to measure the systolic arterial pressure (SBP), the right femoral vein is separated for spare bloodletting, the right common carotid artery is cannulated to the left ventricle, and the pressure converter is connected to measure the left ventricular systolic pressure (LVSP), Connect the ECG port lead. After stabilizing, record the norm...
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