Oral veterinary drug delivery system and/or feed additive delivery system, process for the preparation and use thereof

A feed additive and delivery system technology, applied in the molding or processing of animal feed, pharmaceutical formulations, animal feed, etc., can solve problems such as environmental pollution

Inactive Publication Date: 2006-01-18
安娜玛丽亚.瑟凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unconsumed and unabsorbed pharmaceuticals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Methyltestosterone feed prepared for oral administration

[0073] The amount of active substance introduced in the feed is calculated by means of the daily dose included in the daily feed ration.

[0074] In a 1 L round bottom flask, 1.9970 g of 17α-methyltestosterone (Research Plus Inc. Bayonne, NJ) was dissolved in 300 mL of acetone. For radioisotope labeling in feed preparations, 3.69 mg of 17α-methyl[4- 14 C]-Methyltestosterone (Amersham International Plc Buckinghamshire, UK).

[0075] 105-110 g of Rangen wet salmon feed (4mm) was passed through a 2mm x 1mm copper wire mesh screen. This is done primarily to separate the feed particles that are too fine for the fish to like to ingest. 100 g of sieved feed was added to the solution. The round bottom flask was placed on a Buchi rotary evaporator and rotated slowly at atmospheric pressure (ca. 60 rpm) for 20 minutes. Maintain a 35-40°C water bath. After 20 minutes, the solvent was completely evaporated by connecti...

Embodiment 2

[0077] Preparation of oral methyltestosterone feed with extra desiccation

[0078] Medicated feed pellets were prepared according to Example 1, after the round bottom flask was removed from the rotary evaporator, nitrogen was purged from the flask.

[0079] The weight of the methyltestosterone feed product was 96.64 g.

Embodiment 3

[0081] Analysis of Medicated Feed Pellets

[0082] The content of methyltestosterone determined by a.HPLC

[0083] Three 1 g portions of the prepared feed were extracted with 20 mL methanol in capped vials in a Branson 2200 sonication bath. Sonication was continued for 60 minutes or until the pellet was completely suspended. The water temperature was kept below 40°C with ice. The supernatant was filtered through a 0.22 micron nylon microcentrifuge filter and diluted with the same solvent (a mixture of 1 volume methanol and 1 volume water). Samples were injected onto the HPLC column.

[0084] Use the calibration curve to find the content of methyltestosterone. The mean value of 3 samples was 20.02±0.604 mg methyltestosterone / g feed (CV=3.02%).

[0085] b. Content of 14C-methyltestosterone in methanol extract by liquid scintillation counting

[0086] The total radioactivity per 100 μL of the extract can be directly calculated from the methanol extract obtained in 3a. The ...

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PUM

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Abstract

An oral veterinary drug delivery system and/or feed additive delivery system is disclosed that contains at least one biologically active substance at least to a substantial extent preferably uniformly sorbed into the bulk of a porous carrier, preferably feed; said drug or feed additive delivery system is obtainable by mixing the feed with solution of the biologically active substance for sorption, followed by the evaporation of the solvent. The medicated feed is readily ingested by animals. Processes for the preparation of the oral veterinary drug or feed additive system and uses thereof as pharmaceutical or feed additive are also disclosed. The preparation is carried out in a closed system that is occupationally and environmentally safe. Products of the invention can be used for farmed animals and pets, preferably for farmed fish in freshwater and seawater.

Description

technical field [0001] The present invention relates to an oral veterinary drug delivery system (delivery system) and / or a feed additive delivery system, the system comprising at least one biologically active substance, preferably the substance is uniformly adsorbed in a porous carrier, the present invention also relates to the delivery system Process of preparation and use of said product for domesticated and pet animals, especially fish. Background technique [0002] Oral administration of biologically active substances to animals via feed is a varied field involving the type of delivery system, ie the nature of the active substance and the nature of the feed. Another variable is the distribution of the active substance in the feed, whether it is distributed throughout the feed or only on its surface. Medicated feed can be prepared by adding the active substance to the feed during feed preparation, or by combining the active substance with an already prepared feed product...

Claims

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Application Information

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IPC IPC(8): A23K1/18A23K1/165A23K1/00A61K9/00A61K31/00
CPCA23K1/188A23K1/165A23K1/18A23K1/001A23K1/002A23K40/00A23K40/10A23K20/168A23K50/00A23K50/80A23K20/184A23K40/25A23K40/20
Inventor 安娜玛丽亚.瑟凯
Owner 安娜玛丽亚.瑟凯
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