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Ornidazole buccal tablet and method for preparing the same

An ornidazole and preparation technology, applied in the field of ornidazole buccal preparations and preparation thereof, can solve problems such as large dosage, achieve the effects of reducing dosage, alleviating adverse reactions, and facilitating clinical medication

Inactive Publication Date: 2006-02-08
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, oral administration of metronidazole, tinidazole tablets or capsules is one of the main means of treating periodontitis and pericoronitis, but the dosage of this treatment method is large, 1g / day, and adverse reactions such as mild stomach discomfort, Stomach pain, dizziness and drowsiness are more likely to occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of the ornidazole lozenge of specification 2.5mg of embodiment one

[0014] The prescription for pressing into 1000 tablets is: Ornidazole 2.5g, Mannitol 250g, Lactose 110g, Microcrystalline Cellulose 100g, Citric Acid 7.5g, Aspartame 10.0g, Essence 2.5g, Sodium Chloride 10.0g, 10 An appropriate amount of 70% ethanol aqueous solution of % povidone (containing 4% menthol, 0.2‰ tartrazine) and 2.5 g of magnesium stearate.

[0015] The preparation process is as follows: 1. Ornidazole is passed through a 120-mesh sieve, and other auxiliary materials are passed through a 80-mesh sieve. 2. Weigh the prescribed amount of ornidazole and flavoring auxiliary materials, and mix well. 3. Weigh the prescribed amount of filler and auxiliary materials, and mix well. 4. Add the mixture obtained in 3 to the mixture obtained in 2, and mix well. 5. Add an appropriate amount of 70% ethanol aqueous solution of 10% povidone to make a soft material, pass through a 20-mesh s...

Embodiment 2

[0016] The preparation of the ornidazole buccal tablet of embodiment two specification 5mg

[0017] The prescription for pressing into 1000 tablets is: Ornidazole 5.0g, Mannitol 270g, Lactose 110g, Microcrystalline Cellulose 80g, Citric Acid 10.0g, Aspartame 15.0g, Essence 3.0g, Sodium Chloride 12.0g, 10 An appropriate amount of 70% ethanol aqueous solution of % povidone (containing 4% menthol, 0.2‰ tartrazine) and 2.5 g of magnesium stearate.

[0018] The preparation process is as follows: 1. Ornidazole is passed through a 120-mesh sieve, and other auxiliary materials are passed through a 80-mesh sieve. 2. Weigh the prescribed amount of ornidazole and flavoring auxiliary materials, and mix well. 3. Weigh the prescribed amount of filler and auxiliary materials, and mix well. 4. Add the mixture obtained in 3 to the mixture obtained in 2, and mix well. 5. Add an appropriate amount of 70% ethanol aqueous solution of 10% povidone to make a soft material, pass through a 20-mesh ...

Embodiment 3

[0019] The preparation of the ornidazole buccal tablet of the specification 10mg of embodiment three

[0020] The prescription for pressing into 1000 tablets is: Ornidazole 10.0g, Mannitol 250g, Lactose 110g, Microcrystalline Cellulose 80g, Citric Acid 10.0g, Aspartame 20.0g, Essence 5.0g, Sodium Chloride 15.0g, 10 An appropriate amount of 70% ethanol aqueous solution of % povidone (containing 5% menthol, 0.2‰ tartrazine) and 2.5 g of magnesium stearate.

[0021] The preparation process is as follows: 1. Ornidazole is passed through a 120-mesh sieve, and other auxiliary materials are passed through a 80-mesh sieve. 2. Weigh the prescribed amount of ornidazole and flavoring auxiliary materials, and mix well. 3. Weigh the prescribed amount of filler and auxiliary materials, and mix well. 4. Add the mixture obtained in 3 to the mixture obtained in 2, and mix well. 5. Add an appropriate amount of 70% ethanol aqueous solution of 10% povidone to make a soft material, pass through...

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PUM

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Abstract

The invention discloses an Ornidazole lozenge preparation and its preparing process, which comprises (by weight portions) Ornidazole 0.2-22%, mannitol, sorbitol or isomaltitol 30-60%, lactose 10-40%, crystalline cellulose or starch gum10-40%, aqueous solution of ethanol 50-80%, polyvidon 3-15%, magnesium stearate 0-1% or silica gel powder 0-5%, coloring agent 0-7%, lemon acid 0-3%, aspartame 0-4%, gourmet powder 0-2%, sodium chloride 0-3% and menthanol 0-5%.

Description

technical field [0001] The invention relates to an ornidazole buccal tablet preparation and a preparation method thereof. Background technique [0002] Periodontitis and pericoronitis are common oral infectious diseases, mainly caused by oral anaerobic bacteria infection, and the infection rate is as high as 96.67%-100%. Clinically, the detection rate of anaerobic bacteria in subgingival plaque of periodontitis is over 90%, which is one of the main pathogenic factors of periodontitis; Aeronaerobes are the main cause of the spread of pericoronitis infection. Therefore, choosing appropriate anti-anaerobic bacteria drugs has become an important method for the treatment of oral anaerobic bacterial infectious diseases. At present, oral administration of metronidazole, tinidazole tablets or capsules is one of the main means of treating periodontitis and pericoronitis, but the dosage of this treatment method is large, 1g / day, and adverse reactions such as mild stomach discomfort,...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/20A61P1/02
Inventor 张国盛吴沉陆宏国张锦锋孙田江
Owner YANGTZE RIVER PHARM GRP CO LTD