Honey suckle extract and its preparing process and application

A technology of honeysuckle extract and extract, applied in the field of medicine, can solve the problems of inconvenient use, difficult quality control, limited drug effect, etc., and achieve the effects of simple operation, high moisture absorption, and improved curative effect.

Inactive Publication Date: 2006-02-08
NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the products containing honeysuckle are traditional Chinese medicine products with complex prescriptions. Although they have a certain curative effect, they also have disadvantages such as large dosage, slow onset of effect, inconvenient use, limited efficacy and difficult quality control.

Method used

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  • Honey suckle extract and its preparing process and application
  • Honey suckle extract and its preparing process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Take 100kg of honeysuckle medicinal material (origin: Pingyi, Shandong), add water 1000L and 800L to extract twice, each time for 1.5 hours, adjust the pH of the extract to 1, put it on a D101 macroporous adsorption resin column, and fully elute with water until the effluent is clear and After no reducing sugar reaction, elute with 10% ethanol, collect the ethanol eluate, recover ethanol, concentrate, adjust the pH of the concentrated solution to 3, add ethyl acetate for extraction, recover ethyl acetate, concentrate, and dry to obtain the honeysuckle extract 2.24kg.

[0077] Measured by HPLC method: the content of chlorogenic acid in the honeysuckle extract obtained in the above experiment is 72%.

Embodiment 2

[0079] Take 100kg of honeysuckle medicinal material (origin: Pingyi, Shandong), add water 1500L, 1000L, 1000L to extract 3 times, each time for 1 hour, adjust the pH of the extract to 3, put it on a D201 macroporous adsorption resin column, and fully elute with water until it flows out After the solution is clarified and free of reducing sugar, elute with 30% ethanol, collect the ethanol eluate, recover ethanol, concentrate, adjust the pH of the concentrated solution to 1, add ethyl acetate for extraction, recover ethyl acetate, concentrate, Dried to obtain 2.30kg of honeysuckle extract.

[0080] Measured by HPLC method: the content of chlorogenic acid in the honeysuckle extract obtained in the above experiment is 80%.

Embodiment 3

[0082] Take 100kg of honeysuckle medicinal material (origin: Pingyi, Shandong), add water 2000L, 800L, 800L, 800L to extract 4 times, each time for 0.5 hours, adjust the pH of the extract to 6, put it on a D301 macroporous adsorption resin column, and fully elute with water After the effluent is clear and there is no reducing sugar reaction, elute with 70% ethanol, collect the ethanol eluate, recover ethanol, concentrate, adjust the pH of the concentrated solution to 6, add ethyl acetate for extraction, and recover ethyl acetate. Concentrate and dry to obtain 2.42kg of honeysuckle extract.

[0083] Measured by HPLC method: the content of chlorogenic acid in the honeysuckle extract obtained in the above experiment is 76%.

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Abstract

The invention provides a honeysuckle flower extract and the process for preparing the extract, wherein the main reactive component of the extract is 25 wt% of chlorogenic acid, the preparing process comprises charging 8-20 times by volume of water into honeysuckle flower medicinal material for water extraction 2-4 times, adjusting pH of the extract to 1-6, passing through macroscopic adsorption resin columns, removing foreign substance through water washing, then purging with 10-70% ethanol, collecting the ethanol eluent, reclaiming ethanol, concentrating, adjusting pH of the concentration liquid to 1-6, charging acetic acid ethyl ester for extraction, reclaiming acetic acid ethyl ester, finally concentrating and drying.

Description

technical field [0001] The invention relates to a honeysuckle extract, a method for extracting the honeysuckle extract from the traditional Chinese medicine honeysuckle, formulations of the extract such as tablets, capsules or injections, and the application of the extract in the preparation of antiviral infection drugs, belonging to the field of medicine. Background technique [0002] In recent years, new antiviral drugs have been emerging, but the incidence of viral infections is still persistent, especially the emergence of AIDS and its pathogenic virus in the 1980s, the emergence of SARS virus in the 21st century, and the development of antiviral drugs. Urgency demands. According to the survey, for the treatment of influenza, 65% of consumers will choose Chinese patent medicine for treatment. After the PPA incident, the prohibition of drugs such as Contac and Kangde will free up a market space of about 6.4 billion yuan. Consumers prefer to take traditional Chinese medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K9/20A61K9/08A61K9/48A61P31/12
Inventor 张现涛邵文豪王玮贾树田钱淑芸
Owner NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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