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Pure ursine fat, and its prepn. method

A seal oil and esterification technology, applied in the field of purifying seal oil and its preparation, can solve the problems of low content, sample damage, environmental pollution, etc.

Inactive Publication Date: 2006-04-12
NAT INST FOR THE CONTROL OF PHARMA & BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the structure is more complicated, it has a higher speed operation structure, it is difficult to maintain, and the investment is relatively large
[0048] my country is rich in marine animal oil resources, but the utilization rate is not high, especially the extraction and deep processing technology is relatively backward. Using traditional chemical separation methods not only consumes a lot of solvents, but also causes pollution to the environment and harm to the health of operators. Bringing new impurities and toxic substances into the product
The product seal oil that makes simultaneously has specific fishy smell, and its physical property is relatively poor
However, in the existing molecular distillation separation and purification technology, in the step of esterifying the seal oil raw material, the esterification methods reported in many literatures are two-step esterification, and the steps are cumbersome. Although some are one-step esterification, the conditions Violent, destructive to samples
At the same time, not only the yield of the final product obtained is low, but also the content of three kinds of omega-3 polyene fatty acids (polyunsaturated fatty acid, PUFA)-EPA, DHA, DPA with important biological activity in the product is also very low

Method used

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  • Pure ursine fat, and its prepn. method
  • Pure ursine fat, and its prepn. method
  • Pure ursine fat, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] 1. Esterification treatment of seal oil:

[0139] Take 500ml of seal oil, mix it with 500ml of 0.5mol / L sodium ethoxide containing 0.001% BHT, add glacial acetic acid to adjust the pH value to about 6.5, and obtain ethylated seal oil.

[0140] 2. Molecular distillation

[0141] a) Degassing: The material is preheated at 50°C and enters the molecular distillation device, the feed rate is 650ml / h, the distillation temperature is 80°C, the absolute pressure of the system is 0.050mbar, the speed of the wiper rotor is 110rpm, and the polyene fatty acid ethyl ester enters the heavy component ,

[0142] b) The first step of separation: take the heavy component from the previous step and sample distillation, preheat at 60°C, feed rate 90ml / h, distill at 60°C, system absolute pressure 0.001mbar, wiper rotor speed 100rpm; re-distill four times under the same conditions Second-rate;

[0143] c) The second step of separation: take the heavy component from the previous step, preh...

Embodiment 2

[0146] 1. Esterification treatment of seal oil:

[0147] Take 500ml of seal oil, mix it with 500ml of potassium ethylate containing 0.5mol / L of 0.003% BHT, add glacial acetic acid to adjust the pH value to about 7.1, and obtain ethylated seal oil.

[0148] 2. Molecular distillation

[0149] a) Degassing: The material is preheated at 60°C and enters the molecular distillation device, the feed rate is 720ml / h, the distillation temperature is 80°C, the absolute pressure of the system is 0.040mbar, the speed of the wiper rotor is 140rpm, and the polyene fatty acid ethyl ester enters the heavy component ;

[0150] b) The first step of separation: take the heavy component from the previous step and sample distillation, preheat at 60°C, feed rate 210ml / h, distill at 80°C, system absolute pressure 0.005mbar, wiper rotor speed 140rpm, take the heavy component and re-inject, The distillation temperature was changed to 85°C, the feed rate was 90ml / h, and the others were the same as abo...

Embodiment 3

[0154] 1. Esterification treatment of seal oil:

[0155] Take 500ml of seal oil, mix it with 500ml of potassium ethylate containing 0.7mol / L of 0.005% BHT, add glacial acetic acid to adjust the pH value to about 7.5, and obtain ethylated seal oil.

[0156] 2. Molecular distillation

[0157] a) Degassing: Preheat the material at 70°C and enter the molecular distillation device, the feed rate is 750ml / h, the distillation temperature is 80°C, the absolute pressure of the system is 0.060mbar, the speed of the wiper rotor is 170rpm, and the PUFAE enters the heavy component.

[0158] b) The first step of separation: take the heavy component from the previous step and sample distillation, preheat at 110°C, feed rate 900ml / h, distill at 110°C, system absolute pressure 0.03mbar, wiper rotor speed 300rpm; take the heavy component and re-inject , the conditions were the same as above and the distillation was repeated twice.

[0159] c) The second step of separation: take the heavy comp...

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Abstract

A purified fur seal fat is prepared from natural fur seal fat through esterifying, and multi-stage molecular distilling for purifying the esterified fur seal fat. Its advantages are high contents of EPA, DPA and DHA, and no specific odor.

Description

technical field [0001] The invention relates to a purified seal oil and a preparation method thereof. Background technique [0002] Fur seals are deep-sea mammals that live in cold waters below the Arctic Circle at -50°C. They feed on rare cod, have a thick layer of fat under their skin, and are rich in omega-3 polyene fatty acids. The fur seal oil extracted from fur seal fat in the pollution-free sea area of ​​northern Canada not only contains three important omega-3 polyene fatty acids: EPA (Eic-osapen-taenoic Acid, eicosapentaenoic acid), DPA (Docosapentaenoic Acid, docosahexaenoic acid) and DHA (Docosahexaenoic Acid, docosahexaenoic acid), and the total content is more than 20%. After years of research in the medical field, it has been confirmed that these three fatty acids have a variety of unique biological activities on the human body: EPA can improve blood circulation, soften blood vessels, adjust blood lipids, lower blood pressure and blood sugar, and anti-inflamma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/12A61K35/35
Inventor 徐康森王召乐嘉静李湛君
Owner NAT INST FOR THE CONTROL OF PHARMA & BIOLOGICAL PROD
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