Process for manufacturing wind-up type liver tissue engineering stent

A liver tissue and engineering technology, applied in the field of manufacturing process of wrap-type liver tissue engineering scaffolds, can solve the problems of difficulty in providing continuous treatment, uncontrollable hole distribution, and inability to obtain multi-level microstructures, and achieve customized manufacturing. , the effect of large material exchange capacity

Inactive Publication Date: 2006-05-10
XI AN JIAOTONG UNIV
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Problems solved by technology

[0002] Liver transplantation is the most effective way to treat patients with severe liver disease. However, due to the shortage of donors, the number of liver transplants in the world is only 40,000-60,000 cases per year; Due to the limitation of cell number, local microenvironment and immune rejection, it has not been widely used clinically; as a transitional means before l

Method used

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  • Process for manufacturing wind-up type liver tissue engineering stent
  • Process for manufacturing wind-up type liver tissue engineering stent
  • Process for manufacturing wind-up type liver tissue engineering stent

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Embodiment Construction

[0022] Referring to the accompanying drawings, according to the manufacturing process of the present invention, the microstructure of the natural liver tissue is simulated first, and the bionic design of the liver tissue engineering scaffold template including the vascular network system and the microstructure of liver cell holes is carried out. Convert the CAD model of the designed liver tissue engineering scaffold template into a rapid prototyping file format, and prepare a resin mold with rapid prototyping technology; use the resin mold to prepare a silicone rubber mold containing liver cell holes and vascular network microstructure through a micro-replication process ; For the semi-permeable membrane, the photolithographic slate technology can be used to manufacture the mask containing the fine hole structure, and the imprint mold can be formed by the mask photocuring process or photolithography process; the biological material with good biocompatibility and biodegradation c...

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Abstract

The invention discloses a method for producing the packed liver project bracket. First according to the inner micro-structure of natural liver, processing the bionic design of liver project bracket blood vessel system and the liver hole; using the fast molding micro-complex technique to produce the silicon rubber mould of bionic liver project bracket; plating the biological material with better bioavailability and biodegradability on the silicon rubber mould; packing the liver project bracket mould after removing mould to realize the spatial structure of liver project bracket; and wetting, sopping, cooling and drying the liver project bracket to attain the spatial liver project bracket with high porous property. When in the external culture, the endothelial cell of blood vessel is planted on the blood vessel network system, and the liver cell is planted on the liver cell hole; then, with the degradation of spatial liver project bracket, the endothelial cell can form the blood vessel, and the liver cell can increase and reunite to grow into the liver organization, to supply the base of transforming the artificial liver into natural liver.

Description

technical field [0001] The invention belongs to the field of biomanufacturing in the medical industry, and relates to a manufacturing process of a biodegradable roll-wrapped liver tissue engineering bracket. Background technique [0002] Liver transplantation is the most effective way to treat patients with severe liver disease. However, due to the shortage of donors, the number of liver transplants in the world is only 40,000-60,000 cases per year; Due to the limitation of cell number, local microenvironment and immune rejection, it has not been widely used clinically; as a transitional means before liver transplantation, the extracorporeal artificial liver support system can only complete single functions such as filtration and purification, and it is difficult to provide continuous It cannot replace all the biochemical functions of the human liver; the existing liver tissue engineering scaffolds are mostly prepared by the traditional pore-forming...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61B17/00A61M27/00B01D71/00C12M3/00
Inventor 李涤尘贺健康刘亚雄卢秉恒
Owner XI AN JIAOTONG UNIV
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