Adjuvant of slow release agent used for eye and medicine containing said adjurant and its preparation method

A sustained-release preparation and ophthalmic technology, which is applied in the field of pharmaceutical compositions containing the excipient and its preparation, can solve the problems of poor controllability of preparation quality standards, difficulty in achieving uniform drug delivery, and unstable gel state, etc. The effect of small drug content, maintaining effective drug concentration, and reducing dosing frequency

Inactive Publication Date: 2006-06-14
成都三明药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is a gel in vitro, the gel state is unstable, and the quality standard of the preparation is poorly controllable. The method of use is to apply a small amount to the lower conjunctival sac each time. It is not a one-off but multiple doses. It is used repeatedly and applied with traditional Chinese medicine. It is easy to be polluted; and because it is applied in the lower conjunctival sac, it is difficult to achieve uniform drug administration, resulting in irregular dosage and uneven application, which is inconvenient to use and easy to cause waste

Method used

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  • Adjuvant of slow release agent used for eye and medicine containing said adjurant and its preparation method
  • Adjuvant of slow release agent used for eye and medicine containing said adjurant and its preparation method
  • Adjuvant of slow release agent used for eye and medicine containing said adjurant and its preparation method

Examples

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Embodiment 1

[0030] The preparation of embodiment 1 eye drops of the present invention

[0031] Raw materials: Levofloxacin Hydrochloride 5.0g, Carbomer 974P NF3.0g, Hypromellose E50LV 15.0g, Disodium Hydrogen Phosphate 2.5g, Sodium Dihydrogen Phosphate 5.0g, Sodium Chloride 5.0g, Parkin ethyl ester 0.3g, appropriate amount of 1M sodium hydroxide, water for injection to 1000ml;

[0032] step:

[0033] 1. Take disodium hydrogen phosphate, sodium dihydrogen phosphate and hydroxypropylmethyl cellulose, dissolve in 350ml water for injection, stir continuously to form a transparent solution, and set aside;

[0034] 2. Take carbomer and add it to 300ml water for injection to swell. After the swelling is complete, add it to the material in the above step 1, and keep stirring to form solution A;

[0035] 3. Add levofloxacin hydrochloride and sodium chloride to 100ml of water for injection, stir continuously, after dissolving, a light yellow transparent solution is formed, and set aside;

[0036...

Embodiment 2

[0039] Raw materials: Levofloxacin Hydrochloride 5.0g, Carbomer 974P NF1.0g, Hypromellose E50LV 15.0g, Disodium Hydrogen Phosphate 2.5g, Sodium Dihydrogen Phosphate 5.0g, Sodium Chloride 5.0g, Add 0.3 g of ethyl parkinate, an appropriate amount of 1M sodium hydroxide, and water for injection to 1000 ml; the steps are the same as in Example 1.

Embodiment 3

[0041]Raw materials: Levofloxacin Hydrochloride 5.0g, Carbomer 974P NF5.0g, Hypromellose E50LV 15.0g, Disodium Hydrogen Phosphate 2.5g, Sodium Dihydrogen Phosphate 5.0g, Sodium Chloride 5.0g, Add 0.3 g of ethyl parkinate, an appropriate amount of 1M sodium hydroxide, and water for injection to 1000 ml; the steps are the same as in Example 1.

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Abstract

An adjuvant for the slow-release eye medicine is prepared from carbomer and hydroxypropyl methylcellulose. Said slow-release eye medicine is prepared from levo-ofloxacin hydrochloride and said adjuvant. Its advantages are high biological utilization rate and low irritation to eye.

Description

technical field [0001] The present invention relates to an auxiliary material for ophthalmic sustained-release preparations, in particular to an auxiliary material prepared from carbomer and hydroxypropylmethyl cellulose as main raw materials, and also relates to an auxiliary material containing the auxiliary material Pharmaceutical compositions and methods for their preparation. Background technique [0002] At present, the two most commonly used dosage forms of drugs for the treatment of eye infections are: solution and ophthalmic ointment. Solution-type eye drops, the principle of action is: after dripping into the eyes, the drug will be delivered with the secretion of tears, which is characterized by uniform distribution, but due to the continuous secretion of tears in the conjunctival sac and rapid removal from the nasolacrimal duct, it will be in the conjunctiva. The intracapsular residence time is very short, so the intraocular bioavailability is very low. Frequent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K9/00A61K9/08A61K31/5383A61P27/02
Inventor 阳向波谢永平张媛
Owner 成都三明药物研究所
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