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Process for synthesizing high molecular weight polypeptide polymer

A technology of peptide polymers and high molecular weight, which is applied in the field of synthesis of high molecular weight polypeptide polymers, can solve the problems of high production components, high molecular weight polypeptide polymers cannot be industrialized, and complex synthesis processes, etc., to achieve strong industrialization and improve the quality of agricultural products , the effect of advanced synthesis technology

Inactive Publication Date: 2006-06-28
BOTAO BIO CHEM SCI & TETH JIUJIANG PETROCHEM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, high-molecular-weight polypeptide polymers can also be used as plant nutrition regulators and fertilizer synergists, and can play a very good role. Products cannot be industrialized and applied to actual needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Weigh 147 grams of glutamic acid and 266 grams of aspartic acid, grind them to about 60 mesh in a mortar and mix them evenly. Transfer the white mixture into a round-bottomed flask, install it and stir, and adjust the stirring speed to 20 revolutions per minute. Heat with a silicone oil bath. The temperature was raised from room temperature to 150°C over 1.5 hours and maintained at this temperature for 1 hour, then raised to 250°C over 1 hour and maintained at this temperature for 1 hour. After the reaction was finished, the temperature was lowered to obtain 352 grams of a tan powdery product.

[0020] Take 10 grams of sample, add 50 milliliters of water, add dropwise potassium hydroxide solution to dissolve under stirring, the end point pH value is 8, and measure the weight average molecular weight of the polypeptide polymer to be 8950. (Molecular weight measurement adopts Ubbelohde viscometer according to the national standard JJG 155-79 viscometer verific...

Embodiment 2

[0023] Example 2 Weigh 147 grams of glutamic acid and 133 grams of aspartic acid, grind them to about 20 mu in a ball mill and mix them evenly. Transfer the white mixture into a stainless steel pan, 300mm long by 200mm wide. Put the pan into the muffle furnace to heat. It takes 1.5 hours to raise the temperature from room temperature to 150°C, keep it at this temperature for 1 hour, then raise the temperature to 230°C, take 1.5 hours, and cool down after 2 hours of reaction. The product is a brown soft block that is a high molecular weight polypeptide polymer. It weighs 236.8 grams after crushing. The measured weight average molecular weight was 7540.

Embodiment 3

[0024] Example 3 Weigh 73 grams of glutamic acid and 133 grams of aspartic acid, grind them to a fineness of 200 mesh in a ball mill and mix them. Add water dropwise to the mixture to smooth the mixture into a mud cake. Put it in a crucible with a lid, heat it in a microwave oven, and take a sample after 5 minutes. The polypeptide polymer is a yellow fluffy block. It is a dark yellow fluffy lump, weighing 176.2 grams after crushing. The measured weight average molecular weight was 6100.

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Abstract

The invention relates to a compounding method for high molecular weight polypeptide polymer that uses aspartic acid or aspartic acid and glutamic acid as raw material. After grinding, taking condensation reaction in the reactor, high molecular weight polypeptide that the average molecular weight would be 1000-200000 would be gained. The invention has advanced technology, no harmful to the environment, wide application range, improves the yield of the agricultural product.

Description

technical field [0001] The invention belongs to the technical field of synthesis of high-molecular-weight polypeptide polymers, and in particular relates to the solid phase preparation of high-molecular-weight polypeptide polymers for industrial water treatment and fertilizer synergy by using aspartic acid or aspartic acid and glutamic acid as raw materials for condensation reaction resolve resolution. Background technique [0002] High-molecular-weight polypeptide polymers have good biodegradability and chelating properties, and have been widely used in the fields of biology and pharmaceutical synthesis. Currently, there are many methods for synthesizing such high molecular weight polypeptide polymers, but liquid phase synthesis techniques are generally used. For example, CN1649892A provides a method for synthesizing a polypeptide compound. In an organic solvent, one end group of an amino acid is first protected, and then reacted with another amino acid to form a polypepti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/00
Inventor 朱廷彬
Owner BOTAO BIO CHEM SCI & TETH JIUJIANG PETROCHEM
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