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Traditional Chinese medicine composition and its preparation method and quality control method

A quality control method and composition technology, applied in the field of traditional Chinese medicine composition and its preparation for the treatment of viral influenza, and in the field of traditional Chinese medicine composition and its preparation, capable of solving the problems of unsatisfactory drug treatment methods and unsatisfactory prevention methods, etc.

Inactive Publication Date: 2006-07-19
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Viral influenza includes influenza and common cold. 90-95% of all acute respiratory infections are caused by viruses, which are far more important than other microorganisms. The treatment of viral influenza is the same as other viral diseases, and there is no specific effect The drug treatment methods and preventive measures are not ideal. At present, the main hope is to seek effective treatment prescriptions from traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0051] Banlangen 300g, honeysuckle vine 375g, mountain bean root 150g

[0052] Houttuynia cordata 450g Chonglou 150g Guanzhong 225g

[0053] Angelica dahurica 150g, Artemisia annua 150g, Sichuan Shegan 150g.

[0054] For the above medicinal smell, take Houttuynia cordata and decoct twice with water, filter, concentrate the filtrate to a relative density of 1.03, cool, add ethanol to make the content 50%, let it stand for precipitation, take the supernatant to recover the ethanol until it has no alcohol smell, spare. Add water to decoct the remaining drugs twice, filter, combine the filtrate and Houttuynia cordata extract, concentrate to a clear paste with a relative density of 1.08 (60°C), spray dry (inlet air 180°C, outlet air 90°C), and spray dry powder Add polyethylene glycol-400 in an amount of 320g, propylene glycol 40g, beeswax 24g, add polyethylene glycol 400 to a total of 720g, pass through a colloid mill and grind for 20 minutes to make 2000 soft capsules.

Embodiment 2

[0056] Banlangen 300g, honeysuckle vine 375g, mountain bean root 150g

[0057] Houttuynia cordata 450g Chonglou 150g Guanzhong 225g

[0058] Angelica dahurica 150g, Artemisia annua 150g, Sichuan Shegan 150g.

[0059] The above medicinal flavors are decocted twice with water, filtered, the filtrate is concentrated to a relative density of 1.03, cooled, added ethanol to make the content 50%, left to settle, the supernatant is taken to reclaim the ethanol, and concentrated to a relative density of 1.08 ( 60 ℃) clear paste, spray drying (180 ℃ of air intake, 90 ℃ of air outlet), dry, and the gained dry paste is ground into fine powder, granulates with the 50% ethanol solution of 1% hydroxypropyl methylcellulose, dry ( 60°C), granulate, add 1g of magnesium stearate and an appropriate amount of starch, to a total of 250g, mix well, pack into capsules, and make 1000 capsules, to get final product.

Embodiment 3

[0061] The quality control method of the capsule that above-mentioned composition of the present invention makes:

[0062] Identification:

[0063] a. Take 3g of the content, add 1ml of concentrated ammonia test solution, 20ml of chloroform, plug it tightly, treat it with ultrasound for 20 minutes, filter, evaporate the filtrate to dryness on a water bath, add 1ml of chloroform to the residue to dissolve, and use it as the test solution. Another matrine reference substance plus chloroform made per 1ml solution containing 0.5mg, as the reference substance solution. Test according to thin-layer chromatography (Appendix V IB of "Chinese Pharmacopoeia"), absorb 10 μl each of the test solution and the reference solution, and place them on the same thin layer of silica gel G with sodium carboxymethyl cellulose as the binder. On the board, use ethyl acetate-chloroform-concentrated ammonia test solution (6:4:0.3) as the developer, develop 12cm, take it out, dry it, and spray it with ...

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Abstract

The invention discloses a medicinal composition, which is prepared from isatic root, and honey-suckle stem, subprostrate sophora root, cordate houttuynia, rhizome of Chinese paris, basket fern, dahurian angelica root, sweet wormwood and belamcanda rhizome. The composition has good effect in treating viral infection of upper respiratory tract. The invention also discloses the process for preparing the medicinal composition and the quality control method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating viral colds and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Viral influenza includes influenza and common cold. 90-95% of all acute respiratory infections are caused by viruses, which are far more important than other microorganisms. The treatment of viral influenza is the same as other viral diseases, and there is no specific effect The drug treatment method and preventive means are not ideal. At present, it is mainly hoped to seek effective treatment prescriptions from traditional Chinese medicine. The etiology and pathogenesis of viral influenza have the following basic characteristics. In terms of etiology, the six evils are prevalent, and damp pathogens are often carried. Therefore, the treatment of vir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P31/12A61P31/16G01N30/90G01N33/15
Inventor 胥明
Owner 北京凯瑞创新医药科技有限公司
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