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Slow-released vincamine capsule and its prepn process

A technology of vinpocetine and sustained-release capsules, which is applied in the field of vinpocetine sustained-release capsules and its preparation, can solve problems such as inconvenient movement, and achieve the effects of taking convenience, promoting energy metabolism, and improving blood circulation

Inactive Publication Date: 2006-08-02
HONGGUAN BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since most of these patients are elderly patients with limited mobility and mental decline, but they need to take medicine for a long time, the common preparation of this product needs to be taken 3 times a day, which brings them a lot of inconvenience.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation formula of the present invention is made up of following components:

[0035] (1) Blank ball core:

[0036] Sucrose Starch Ball Core 30.0g

[0037] (2) Active drug layer:

[0038] Changchun West 15.0g

[0039] Citric acid 45.0g

[0040] Starch 100.0g

[0041] Micronized silica gel 1.4g

[0042] Proper amount of ethanol

[0043] (3) Slow-release coating layer:

[0044] Eudragit L100 25.0g

[0045] Triethyl citrate 2.7g

[0046] Talc powder 14.0g

[0047] Titanium dioxide 4.5g

[0048] Ethanol to 410.0g

[0049] A total of 1000 capsules were made

[0050] Preparation steps:

[0051] (1) in the centrifugal coating granulator, with ethanol solution as binding agent, wrap the vinpocetine active drug layer that is made up of vinpocetine, citric acid, starch, micropowder silica gel on the blank ball core, 60 ℃ drying, to get Vinpocetine pills;

[0052] (2) In the centrifugal coating granulator, wrap the slow-release coating layer coating solution...

Embodiment 2

[0055] (1) Blank ball core:

[0056] Microcrystalline Cellulose Core 15.0g

[0057] (2) Active drug layer:

[0058] Vinpocetine 30.0g

[0059] Citric acid 15.0g

[0060] Mannitol 10.0g

[0061] Sodium Lauryl Sulfate 1.4g

[0062] 2% PVP ethanol solution appropriate amount

[0063] (3) Slow-release coating layer:

[0064] Ethylcellulose 7.0g

[0065] PVP 0.7g

[0066] Talc powder 7.0g

[0067] Ethanol to 140ml

[0068] A total of 1000 capsules were made

[0069] Preparation steps:

[0070] (1) in the fluidized bed coating granulator, with the ethanol solution of 2%PVP as binding agent, wrap the vinpocetine active drug layer on the blank ball core, 60 ℃ of drying, get vinpocetine pill;

[0071] (2) In the fluidized bed coating granulator, wrap the sustained-release coating layer coating solution on the Vinpocetine pills, control the amount of the coating solution according to the drug release rate, and dry at 40°C for 2 hours to obtain Changchun Xetine sustained-relea...

Embodiment 3

[0074] (1) Blank ball core:

[0075] Sucrose Starch Ball Core 50.0g

[0076] (2) Active drug layer:

[0077] Vinpocetine 7.5g

[0078] Tartaric acid 52.5g

[0079] Lactose 50.0g

[0080] 50% ethanol solution of 2% HPMC appropriate amount

[0081] (3) Slow-release coating layer:

[0082] Eudragit RS 30D 12.5g

[0083] Eudragit RL 30D 12.5g

[0084] Dibutyl sebacate 0.8g

[0085] Talc powder 4.2g

[0086] Water 25.0g

[0087] A total of 1000 capsules were made

[0088] Preparation steps:

[0089] (1) In a fluidized bed coating granulator, the vinpocetine active drug layer is made into a suspension with 50% ethanol solution of 2% HPMC, sprayed on the blank ball core, and dried at 60°C to obtain Changchun Xetine pills;

[0090] (2) In the fluidized bed coating granulator, wrap the sustained-release coating layer coating solution on the Vinpocetine pills, control the amount of the coating solution according to the drug release rate, and dry at 40°C for 2 hours to obtai...

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PUM

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Abstract

The present invention provides one kind of slow-released vincamine capsule and its preparation process. The slow-released vincamine capsule contains slow-released vincamine micro pills comprising blank micro pill, active medicine layer and releasing coating. The slow-released vincamine capsule may have different micro pill combination for ideal slow-release speed for the patient to take 1-2 times a day. Compared with other vincamine preparations, the preparation of the present invention has the advantages of smooth blood medicine concentration, long maintenance time, less toxic side effect, high patient dependence in taking medicine, etc.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, and relates to a sustained-release capsule dosage form of a cerebral vasodilator, in particular to a sustained-release capsule of vinpocetine and a preparation method thereof. Background technique [0002] Vinpocetine (Vinpocetine, chemical name is ethyl apovincamine-22-acetate), is a cerebral vasodilator, can inhibit the activity of phosphodiesterase, increase the role of the messenger c-GMP in vascular smooth muscle relaxation, selectivity In addition, it can inhibit platelet aggregation, reduce human blood viscosity, enhance red blood cell deformability, improve blood fluidity and microcirculation, promote brain tissue uptake of glucose, increase brain oxygen consumption, and improve brain metabolism. This product can reach the peak plasma concentration within 1 hour after oral administration, and the half-life is about 2-4 hours. It is clinically used to improve various neurological or mental s...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K9/52A61P9/10A61P25/00
Inventor 张文伟郭殿武谢纲郑文
Owner HONGGUAN BIO PHARMA CO LTD
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