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Chemical prepn process of composite hydroxyapatite/collagon layer on the surface of Ni-Ti alloy

A hydroxyapatite and nickel-titanium alloy technology, applied in medical science, prosthesis, etc., can solve problems such as the inability to approximate the growth process of human bone, the inability to fully exert biocompatibility, and the inability to fully simulate human bone, etc. The effect of low processing temperature, high bonding strength and uniform surface

Inactive Publication Date: 2006-08-02
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the coatings prepared on the surface of nickel-titanium alloy are simple hydroxyapatite coatings, which cannot completely simulate the components of human bone; and the hydroxyapatite / collagen composite layer prepared step by step by some current methods cannot approximate Simulate the growth process of human bone, and there is a big difference with the structure of human bone, so the biocompatibility cannot be fully utilized in actual work

Method used

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  • Chemical prepn process of composite hydroxyapatite/collagon layer on the surface of Ni-Ti alloy
  • Chemical prepn process of composite hydroxyapatite/collagon layer on the surface of Ni-Ti alloy
  • Chemical prepn process of composite hydroxyapatite/collagon layer on the surface of Ni-Ti alloy

Examples

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example 1

[0011] Take a NiTi alloy matrix bulk sample (10×10×3mm 3 ), polished to 800# step by step with water sandpaper, then ultrasonically cleaned in deionized water, and then sealed and dried at room temperature. The dried sample was put into 30% nitric acid and treated at 50°C for 30min. After ultrasonic cleaning with deionized water and airtight drying at room temperature, place it in a sodium hydroxide solution with a concentration of 1.2M and soak for 2 hours at 100°C. After that, the sample needs to be ultrasonically cleaned with deionized water and airtightly dried at room temperature deal with. The obtained sample was placed in Na 2 HPO 4 Soak in a supersaturated aqueous solution at 40°C for 8 hours, and then in Ca(OH) 2 Soak in supersaturated aqueous solution at 25°C for 8h. After that, the pre-calcified sample was ultrasonically cleaned with deionized water and airtightly dried at room temperature, and then soaked in the composition: Na + 213.0mmol / L, Cl - 187.5mmo...

example 2

[0013] Take a NiTi alloy matrix bulk sample (10×10×3mm 3 ), polished to 800# step by step with water sandpaper, then ultrasonically cleaned in deionized water, and then sealed and dried at room temperature. The dried sample was put into 50% nitric acid and treated at 60°C for 10 minutes. After ultrasonic cleaning with deionized water and airtight drying at room temperature, place in 2M sodium hydroxide solution and soak for 5 hours at 100°C. After that, the sample needs to be ultrasonically cleaned with deionized water and airtightly dried at room temperature. . The obtained sample was placed in Na 2 HPO 4 Soak in a supersaturated aqueous solution at 40°C for 4 hours, and then in Ca(OH) 2 Soak in supersaturated aqueous solution at 40°C for 12h. After that, the pre-calcified sample was ultrasonically cleaned with deionized water and airtightly dried at room temperature, and then soaked in the composition: Na + 213.0mmol / L, Cl - 187.5mmol / L, HCO 3 - 40.5mmol / L, K + ...

example 3

[0015] Take a NiTi alloy matrix bulk sample (10×10×3mm 3 ), polished to 800# step by step with water sandpaper, then ultrasonically cleaned in deionized water, and then sealed and dried at room temperature. The dried sample was put into 30% nitric acid and treated at 60°C for 30min. After ultrasonic cleaning with deionized water and airtight drying at room temperature, place it in a sodium hydroxide solution with a concentration of 1.2M and soak for 6 hours at 100°C. After that, the sample needs to be ultrasonically cleaned with deionized water and airtightly dried at room temperature deal with. The obtained sample was placed in Na 2 HPO 4 Soak in a supersaturated aqueous solution at 40°C for 15 hours, and then in Ca(OH) 2 Soak in supersaturated aqueous solution at 25°C for 8h. After that, the pre-calcified sample was ultrasonically cleaned with deionized water and airtightly dried at room temperature, and then soaked in the composition: Na + 213.0mmol / L, Cl - 187.5mm...

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Abstract

The present invention belongs to the field of biological bone material preparing technology. The chemical preparation process of composite hydroxyapatite / collagen layer on the surface of Ni-Ti alloy includes the following steps: polishing, washing and drying the Ni-Ti alloy substrate and acid-alkali treatment; pre-calcifying of the substrate inside Na2HOP4 and Ca(OH)2 solution; and finally setting in simulating body fluid containing collagen to grow the composite hydroxyapatite / collagen layer. The process has the features of simple activating treatment and low acid-alkali treatment temperature. In the simulating body fluid containing collagen, hydroxyapatite and collagen are deposited simultaneously to form the composite hydroxyapatite / collagen layer with homogeneous surface and firm combination to the substrate. The present invention is suitable for implant with complicated shape.

Description

Technical field: [0001] The invention relates to a chemical preparation method of a hydroxyapatite / collagen composite layer on the surface of a nickel-titanium alloy, which belongs to the preparation technology of biological bone materials. Background technique: [0002] On the basis of analyzing the micro-assembly, biological function and formation mechanism of natural biomaterials, the developed biomedical biomaterials are widely used in the repair and replacement of human tissues and organs. Nickel-titanium memory alloy not only has a special shape memory effect, but also has high strength, small specific gravity, low elastic modulus, and good fatigue strength, which has attracted widespread attention. However, the application of nickel-titanium alloy has been questioned and limited due to its poor biocompatibility. If a coating with better biocompatibility and stability is covered on the surface of NiTi alloy, the good mechanical properties of NiTi alloy and the excelle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40
Inventor 杨贤金崔振铎蔡彦丽魏强朱胜利梁春永
Owner TIANJIN UNIV
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