Large focus domain forming method for phase control array focusing supersonics

Abstract

The present invention relates to supersonic focusing phase control array method to form large focus domain. Heat field shape is set based on the size and shape of the target tissue, and the supersonic focusing phase control array transducer has its element exciting signal phases and amplitudes regulated to generate various modes of multiple focus supersonic field distribution, so as to form required focus domain shape and size, provide supersonic energy for heating the target tissue and form intracorporeal local stereo heating region up to 30 mm. For even larger target tissue, the divisional synthesis mode is adopted. The formed multiple focus supersonic field may be exchanged or rotated to ensure homogeneous heat distribution. The present invention makes it possible to realize shaped directional heating of deep body target tissue, and this provides the technological foundation for the treating technology of directional opening of heat sensitive liposome and the heat synergistic effect of carried heat sensitive medicine.

Description

technical field [0001] The invention relates to a method for forming a large focal region of a phased array focused ultrasound, which is used to regulate the phase and amplitude of the excitation signals of each array element in a phased array focused ultrasonic transducer, thereby forming a focal region of a required shape and size. Effective treatment of cancer patients. It belongs to the technical field of biomedical engineering. Background technique [0002] As a drug carrier, the nanoparticle thermosensitive liposome with temperature as the key switch can carry the drug into the target tissue of the human body. When the target tissue of the human body is directional and conformally heated to 40-45°C, the liposome shell is opened, and the drug loaded in it is released at a specific point. This technology not only increases the local concentration of the drug, improves the lethality of tumor cells in the target tissue, but also avoids the harm caused by systemic adminis...

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Problems solved by technology

This technology has obvious shortcomings: the system uses a planar ultrasonic transducer, and its sound waves radiate along the vertical direction, and the energy is dispersed. The lower the sound intensity in the body, in order to ensure sufficient effective heating depth, the ultrasonic transducer must have a high enough radiation power, which will make the patient feel pain, burn the skin on the body surface, and even superficial tissues; only 16 arrays The elements are arranged and combined to form different shapes, and the conformability is poor; when the ultrasonic energy is radiated to the target tissue in the body, only the attenuation is not enhanced, so the effective heating depth is short, and it is difficult to meet the treatment requirements

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