Method for picking-up effective ingredient of Imperatorin of Chinese traditional medicine cnidium fruit, and element of cnidium fruit

The technology of osthole and imperatorin is applied in the field of separation of natural plant medicinal components, which can solve the problems of low content of medicinal active components, existing organic residues, low extraction rate and the like, and achieves less impurities, low cost, The effect of high content of active ingredients

Inactive Publication Date: 2006-12-06
XI AN JIAOTONG UNIV
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Problems solved by technology

However, these methods have disadvantages such as low extraction rat

Method used

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Example Embodiment

[0016] The following is the specific implementation of the present invention given by the inventor, combined with a further detailed description of the preferred embodiments.

[0017] 1. Supercritical extraction of Cnidium monnieri medicinal materials

[0018] Take 1,000 g of the Cnidium acuminata fruit powder, smash, pass through a 20-mesh sieve, weigh the powder, and place it in an extraction kettle. After the refrigeration device, the extraction kettle and the separation kettle heating device work normally, turn on the compression pump to pressurize to 20.0MP, the temperature is 40℃, and adjust the carbon dioxide (CO 2 ) Circulating extraction with a flow rate of 40kg / h, the desorption pressure and desorption temperature of the separation tank are 6MP and 50°C, respectively, after 4h of extraction, the extract is fractionated to obtain the Cnidium monnieri extract.

[0019] 2. Separation and purification of the effective components in the extract of Cnidium monnieri

[0020] Ta...

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Abstract

This invention relates to a method for extracting the effective components from Cnidium monnier. The method comprises: (1) pulverizing Cnidium monnier fruits, and sieving with a 20 mesh sieve; (2) extracting in a supercritical extraction apparatus to obtain Cnidium monnier extract; (3) dissolving Cnidium monnier extract with the same amount of ether under ultrasonication, filtering, adding the same amount of petroleum ether to the filtrate, standing at a low temperature, and filtering to obtain crystalline substances and the filtrate; (4) recrystallizing the crystalline substances with ethanol to obtain imperatorin; and (5) volatilizing ether from the filtrate, standing at a low temperature, and filtering to obtain crystals; (6) recrystallizing with ethanol to obtain osthole. The purity of the obtained compounds can be determined by thin-layer chromatography, high performance liquid chromatography and melting point detection method. The method has such advantages as high product purity, high yield, good repeatability, simple process, low toxicity.

Description

technical field [0001] The present invention relates to the separation of medicinal components of natural plants, and relates to a method for extracting traditional Chinese medicine, in particular to a method for extracting imperatorin and osthole, the effective components of the traditional Chinese medicine Cnidium Fructus Cnidii. The method separates imperatorin and Osthole can be used as a reference substance or raw material for pharmaceutical production, and can also be used as a single component for pharmaceuticals. Background technique [0002] Cnidium monnieri (Cnidium monnieri (L.) Cuss) is the dry ripe fruit of Umbelliferae Cnidium monnieri (L.) Cuss. Sexually hard and warm, bitter in the mouth. The 2005 edition of "Chinese Pharmacopoeia" records that it has the effects of warming the kidney and strengthening yang, drying dampness, dispelling wind, and killing insects. Traditional Chinese medicine is mainly used to treat vulvar eczema, pru...

Claims

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Application Information

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IPC IPC(8): C07D493/04C07D311/16
CPCY02P20/54
Inventor 杨广德贺浪冲张继业张莉张燕曹永孝边晓丽
Owner XI AN JIAOTONG UNIV
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