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Application of cysteamine and derivative thereof in preparation of medicament for improving bird flu antibody potency

A technology of antibody titer and cysteamine, which is applied in the fields of application, antiviral agents, antibody medical components, etc., can solve the problems of cysteamine and its derivatives to improve the antibody titer of bird flu vaccine, and achieve the improvement of antibody titer , control the amount, easy to use the effect of the amount

Inactive Publication Date: 2006-12-27
华扩达动物科技(I.P.5)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about cysteamine and its derivatives improving the antibody titer of bird flu vaccine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In a jacketed reactor lined with polytetrafluoroethylene and equipped with a stirrer coated with polytetrafluoroethylene, add 3500g of 75% cysteamine hydrochloride ethanol solution under nitrogen protection, then add 1100g beta-cyclodextrin, The mixture was then heated and stirred at 40°C for 3 hours. After the heating was stopped, stirring was continued for 2 hours, and the product was vacuum-dried at a temperature of 45° C., and the obtained product was ground and passed through a 40-mesh sieve.

[0036] In a tank type mixer, 4000 g (by weight on a dry basis) of the contained cysteamine obtained above, 2000 g of powdered cellulose, and 1000 g of hydroxypropyl starch and 1700 g of microcrystalline cellulose were added under a dry environment. Mix the above ingredients thoroughly, and add an appropriate amount of absolute ethanol. The mixture obtained is a soft material with suitable hardness. The mixture is granulated with a granulator under the protection of nitroge...

Embodiment 2

[0042] In a jacketed reactor lined with polytetrafluoroethylene and equipped with a stirrer coated with polytetrafluoroethylene, add 4000g of 75% cysteamine ethanol solution under nitrogen protection, and then add 1300g of methyl β-cyclopaste After refining, the mixture was heated and stirred at 40°C for 3 hours. After the heating was stopped, stirring was continued for 2 hours, and the product was vacuum-dried at a temperature of 45° C., and the obtained product was ground and passed through a 40-mesh sieve.

[0043] In a tank type mixer, 4000 g (by weight on a dry basis) of the contained cysteamine obtained above, 3000 g of silicon dioxide, and 1300 g of microcrystalline cellulose and 1700 g of microbial alginate were added under a dry environment. Mix the above ingredients thoroughly, and add an appropriate amount of absolute ethanol. The mixture obtained is a soft material with suitable hardness. The mixture is granulated with a granulator under the protection of nitroge...

Embodiment 3

[0047] Weigh the following substances: cysteamine 300.0g, vitamin C 5.0g, mannan-oligosaccharide 20.0g, dissolve the above-mentioned substances in 300ml of normal saline, fully dissolve and mix them uniformly and store them in a sealed plastic reagent bottle to obtain Injection of the present invention.

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Abstract

Disclosed is an applocation of cysteamine and a derivant thereof in preparation of medicament for improving avian influenza vaccine antibody potency, comprising feeding animals with cysteamine and the derivant thereof as feed addictive or with final feed prepared from cysteamine and the derivant thereof and basic feed; or preparing an injection of cysteamine and the derivant thereof, enjecting them into animal bodies directly or as ejection adjuvant after emulsified with mineral oil, and injecting beforehand or at the same time of vaccine injection. The invention is provided with convenience of use, ease for quantity control, and security for use.

Description

technical field [0001] The invention relates to cysteamine and its derivatives, in particular to the application of cysteamine and its derivatives in the preparation of medicaments for improving the titer of avian influenza vaccine antibodies. Background technique [0002] At present, the prevalence of avian influenza seriously threatens human health and safety, and has caused a fatal blow to the poultry industry, as well as huge economic losses. [0003] Cysteamine is a very active substance that exists widely in nature, and it has a wide range of physiological regulation effects. For example, it is a depleting agent of somatostatin (SS) in animals. By consuming SS, it can increase the level of growth hormone (GH) that can promote animal growth, play a role similar to exogenous GH, and promote animal growth and lactation. Cysteamine has been used directly as an additive or as a premixed feed in the field of medicine and in promoting animal growth, improving meat quality an...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K31/145A61K39/145A61K9/107A61P31/16A23K1/17A23K20/195
Inventor 闻芹堂池豪徐金先
Owner 华扩达动物科技(I.P.5)有限公司