Fluorescent nano-particle with surface biological function, its production and use

A biological functionalization and fluorescent nanotechnology, which is applied in biological testing, fluorescence/phosphorescence, material inspection products, etc., can solve the problems that fluorescent nanomaterials have the function of binding biomolecules at the same time, and achieve trace detection and trace reaction. , smooth surface and uniform particle distribution
CN1896738AInactive Publication Date: 2007-01-17SHANGHAI NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI NORMAL UNIVERSITY
Publication Date
2007-01-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to a preparation method and its application of nuclear shell fluorescence nanometer particle whose surface living things is functional. The particle has nuclear shell structure, fluorescence material is hit in the inner core; the outer shell is composed of fluorescence transparency material; and there is embellishing organic function group in the outer covering. The nanometer particle is formed by the reversal tiny emulsion method, and doing chemical modification in the surface to make it to be biology functional nanometer particle. The nanometer particle has important application prospect in the fields such as cell biology, ultramicrochemistry, within the AMD chemistry, living things big molecule detecting and medical in-vivo diagnosing.
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Description

Background technique

[0001] In recent years, biological detection technology has developed rapidly, among which the development of ultra-sensitive fluorescence detection technology provides conditions for the study of biomolecules in complex environments. The establishment of ultra-sensitive fluorescence detection technology depends on the successful development of non-toxic and biocompatible luminescent materials.

[0002] Organic fluorescent substances are classic fluorescent substances. Although organic fluorescent substances have their shortcomings due to their inherent properties, such as fluorescence efficiency problems, etc., compared with current inorganic fluorescent substances, organic fluorescent substances still have a wide range of applications. Such as applied to flow cytometry, applied to antibody labeling and so on.

[0003] Biofunctional materials have always been a hot field in the field of materials research. In biofunctional materials, nanomaterials have a...

Claims

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