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Compound isatis root effervescence tablet and its preparing method

A compound banlan and effervescent tablet technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and medical raw materials derived from angiosperm subphylum, etc., can solve the problems of loss of active ingredients, precipitation, and low bioavailability.

Inactive Publication Date: 2007-01-24
重庆百花生物医药集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dosage forms all have some shortcomings, such as the oral liquid loses a lot of active ingredients in the process of alcohol precipitation, thus affecting the curative effect; capsules are not suitable for children and the elderly; Incomplete dissolution with granules, easy to produce precipitation, high dosage; the clarity of injection is difficult to control and the cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 of the present invention: Radix isatidis 254.9g, Daqingye 38.2g, sodium bicarbonate 229.4g, citric acid 191.2g, sodium carboxymethyl starch 76.5g, microcrystalline cellulose 191.2g, starch 325g, cross-linked polyethylene Pyrrolidone 38.2g, polyethylene glycol 6000 57.4g, micronized silica gel 30g, aspartame 10g

[0043] Weigh Radix Radix and Folium Folium, add 95% ethanol, reflux and extract twice, each time for 1.5 hours, filter, the filtrate recovers ethanol and concentrates to a thick paste with a relative density of 1.35 at 60°C; Once for 1 hour, filter, the filtrate is concentrated to a thick paste with a relative density of 1.35 at 60°C, combine the above thick paste, add sodium bicarbonate, citric acid, sodium carboxymethyl starch, microcrystalline cellulose, starch, and cross-linked polyethylene Rolidone and macrogol 6000 are made of soft materials, granulated, and then micro-powdered silica gel and aspartame are added, and compressed into tablets to o...

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PUM

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Abstract

The present invention is a kind of kind of compound isatis root effervescent tablet and its preparation process. The compound isatis root effervescent tablet is prepared with isatis root, isatis leaf and proper amount of supplementary material. Compared with available technology, the compound isatis root effervescent tablet of the present invention has the advantages of fast medicine release, quick acting, high bioavailability, high stability, etc. and is especially suitable for children, old people and patient with dysphagia.

Description

Technical field: [0001] The invention relates to a compound isatidis effervescent tablet and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Isatis root is the root of the cruciferous plant Isatis indigo, also known as Cao Daqing, and the leaves are called Daqingye. It has the functions of clearing away heat and detoxification, cooling blood and relieving throat. It is used for warm toxins and spots, dark purple tongue, mumps, sore throat, rotten throat Dansha, big head plague, erysipelas, and carbuncle. Clinically, it is widely used in the treatment of cold, fever, sore throat, mumps, tonsillitis, various hepatitis, Japanese encephalitis, etc. Existing isatidis preparations mainly include granules, tablets, syrups, oral liquids, capsules, injections, granules and the like. These dosage forms all have some shortcomings, such as the oral liquid loses a lot of active ingredients in the pr...

Claims

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Application Information

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IPC IPC(8): A61K36/315A61K36/19A61K9/20A61K9/46A61P11/04A61P29/00A61P1/16A61P31/12
Inventor 黄文荣
Owner 重庆百花生物医药集团股份有限公司
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