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Method for preparing Nosiheptide premixed agent

A technology of nosiheptide and premix, which is applied in the field of biopharmaceuticals and can solve problems such as the preparation method of nosiheptide premix that has not yet been seen.

Inactive Publication Date: 2007-01-24
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But take a comprehensive look at domestic and foreign literature, do not see the report of relevant nosiheptide premix preparation method yet

Method used

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  • Method for preparing Nosiheptide premixed agent
  • Method for preparing Nosiheptide premixed agent
  • Method for preparing Nosiheptide premixed agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Nosipeptide-producing bacteria Z13 was inoculated in the seed tank, grown for 40-48 hours, inserted into a 30-ton fermenter with 5% inoculum, with 1:1 ventilation, controlled temperature at 28-30°C, and stirred at 160-180 rpm According to the pH, sugar content and thallus morphology, the feed is divided into 9 days, and 20 tons of material are discharged, and the fermentation unit per liter reaches 2.3 grams. After extracting 23.46 kg of nosiheptide (purity 85%); add starch, soybean cake powder, rice bran powder, corn flour, bran, rice protein powder, stone powder (CaCO 3 ), zeolite powder and other auxiliary materials were diluted step by step and mixed thoroughly to obtain 7.98 tons of premix (0.25% specification).

Embodiment 2

[0030] Nosiheptide-producing bacterium Z14 was inoculated in the seed tank, grown for 40-48 hours, inserted into a 30-ton fermenter with 5% inoculum, with 1:0.5 ventilation, controlled temperature at 28-30°C, and stirred at 160-180 rpm According to the pH, sugar content, and thallus morphology, feed was fed, cultivated for 9 days, and 20 tons of material were discharged, with a fermentation unit of 3.2 grams per liter. After extracting 32.6 kg of nosiheptide (purity 85%); add starch, soybean cake powder, bran, rice bran powder, rice protein powder, stone powder (CaCO 3 ), zeolite powder, etc., were diluted step by step and mixed thoroughly to obtain 11.08 tons of premix (0.25% specification).

Embodiment 3

[0032] Nosiheptide-producing bacterium Z15 was inoculated in the seed tank, grown for 40-48 hours, inserted into a 30-ton fermenter with 5% inoculum, with 1:0.5 ventilation, controlled temperature at 28-30°C, and stirred at 160-180 rpm According to the pH, sugar content, and bacterium morphology, feeding was carried out for 9 days, and the output was 21 tons, and the fermentation unit per liter reached 4.2 grams. After extracting 44.982 kg of nosiheptide (purity 85%); add starch, soybean cake powder, rice bran powder, bran, corn flour, stone powder (CaCO 3 ), zeolite powder, etc., were diluted step by step, mixed well, and 7.65 tons of premix (0.5% specification) were obtained.

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Abstract

The present invention belongs to the field of biomedicine preparing technology, relates to preparation of feed medicine additive, and is especially preparation process of pre-mixed preparation containing Nosiheptide as one kind of sulfur-containing polypeptide. The pre-mixed preparation containing Nosiheptide is prepared through the steps of preparing Nosiheptide generating microbe by means of gene engineering technology, Nosiheptide fermentation, separating extraction and adding supplementary material, stepped dilution, and mixing. The preparation process has raised oxygen utilizing efficiency of streptomycete, raised Nosiheptide yield and lowered production cost.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and relates to a method for preparing a medicinal feed additive, in particular to a method for preparing a sulfur-containing polypeptide antibiotic nosiheptide premix. Background technique: [0002] Feed safety is the basic point of green and environmentally friendly food. my country has a vast territory and a large population. With the acceleration of reform and opening up and the improvement of people's living standards, the demand for livestock, poultry and aquatic products is also increasing. In addition, my country is a large agricultural country, and the export volume of poultry and livestock products is very large, but the problem of drug residues is very serious. Therefore, the research and development of green feed additives is very necessary for the protection of people's health and the development of my country's agricultural economy. In July 2001, the Ministry of Agriculture issued t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10C12P21/02C12N1/21A61P31/04
Inventor 周珮陈贵才冯美卿李继扬万睿文勇
Owner FUDAN UNIV
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