Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Powder injection of cinepazet maleate and its prepn. method

A technology of cinepazide maleate and cinepazide acid powder, which is applied in powder transportation, non-active ingredients of polymer compounds, liquid transportation, etc., which can solve the problems of inconvenient transportation and storage, and achieve good product stability , not easy to decompose, improve the effect of curative effect

Inactive Publication Date: 2007-01-31
王义梅
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, cinepazide maleate is a small-capacity injection, but some are not convenient for transportation and storage. For this reason, the present invention has developed a kind of cinepazide maleate powder injection, which makes the transportation, storage and use of medicine Both increase the stability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, take by weighing cinepazide maleate 10g, mannitol 10g, hydroxypropyl-beta-cyclodextrin 100g, add sterile water for injection 1000ml, stir to make it dissolve, measure the pH value of the solution 4.8~5.5 , add medicinal activated carbon, filter, and then filter the filtrate with a 0.22 μm microporous membrane filter, and fill it in a sterilized vial. Pre-freeze at -30-40°C for 2-3 hours, sublimate and dry at -36-20°C for 10-12 hours, dry at 30°C for 25-30 hours, cover, crimp, and pack to obtain cinnamon maleate. Pazide freeze-dried powder injection.

Embodiment 2

[0025] Example 2. Weigh 10 g of cinepazide maleate, 10 g of mannitol, and 1.5 g of polysorbate 80, add 1000 ml of sterilized water for injection, stir to dissolve it, measure the pH value of the solution to 4.8 to 5.5, add medicinal Activated carbon, filtered, and the filtrate was filtered with a 0.22 μm microporous membrane filter, and filled into sterilized vials. Pre-freeze at -30-40°C for 2-3 hours, sublimate and dry at -36-20°C for 10-12 hours, dry at 30°C for 25-30 hours, cover, crimp, and pack to obtain maleic acid Cinepazide freeze-dried powder injection.

Embodiment 3

[0026] Example 3. Weigh 10 g of cinepazide maleate, 10 g of mannitol, and 50 g of poloxamer, add 1000 ml of sterilized water for injection, stir to dissolve it, measure the pH value of the solution to 4.8 to 5.5, and add medicinal activated carbon , filtered, and the filtrate was filtered with a 0.22 μm microporous membrane filter, and filled into sterilized vials. Pre-freeze at -30-40°C for 2-3 hours, sublimate and dry at -36-20°C for 10-12 hours, and then dry at 30°C for 25-30 hours, cover, crimp, and pack to obtain cinpezil maleate. Freeze-dried powder for injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A powder injection of cinepazide maleate is proportionally prepared from cinepazide maleate, solubilizer and filler through mixing for dissolving, decoloring by medical activated carbon, filtering with millipore membrane, dewatering and drying.

Description

technical field [0001] The invention relates to a powder injection of a drug for treating cardiovascular and cerebrovascular diseases, in particular to a powder injection of a drug for treating cardiovascular and cerebrovascular diseases containing cinepazide maleate as an active component. Background technique [0002] At present, only Beijing Sihuan Pharmaceutical Co., Ltd. exclusively produces cinepazide maleate (National Pharmaceutical Approval H20020124, approved for production on April 9, 2002); Approved for production on April 9). And cinepazide maleate injection is an existing national drug standard. [0003] Cinepazide Maleate Injection (Klinao) is a new type of cardiovascular and cerebrovascular drug developed by the Institute of Materia Medica, Chinese Academy of Medical Sciences after years of hard work. It is produced by Beijing Sihuan Pharmaceutical Co., Ltd. and is currently the exclusive domestic drug. Variety. Its unique pharmacological characteristics ar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/496A61K47/40A61K47/34A61K9/10A61K47/10A61K47/26
Inventor 王义梅
Owner 王义梅
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com