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Biodegradable polyester containing phosphatidylcholine group and its preparation method

A technology for biodegrading polyester and phosphatidylcholine groups, which can be used in medical preparations, pharmaceutical formulations, medical science and other directions of non-active ingredients, and can solve the problem of limited number of phosphatidylcholine groups, limited contribution, and biocompatibility. It is easy to control the process, the method is simple, and the selection range is large.

Inactive Publication Date: 2007-01-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the number of phosphatidyl cholyl groups introduced in these published documents or patents is limited in the polymer chain of the polyester, so the contribution to the properties of the entire material is limited, and it is not possible to obtain different drugs that meet the needs of controlled release of drugs and tissue engineering. Different materials with good biocompatibility

Method used

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  • Biodegradable polyester containing phosphatidylcholine group and its preparation method
  • Biodegradable polyester containing phosphatidylcholine group and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0032]Mix 0.01 part of glycerol phosphatidylcholine with 10 parts of recrystallized and purified lactide, dry it, then add 1% metal zinc powder catalyst based on the mass of lactide and mix it under vacuum at 100mmHg and temperature 50℃ Drying at low temperature for 24 hours, sealing the tube under vacuum and reacting at 150° C. for 20 hours to obtain the biodegradable polyester (I) with single side chain containing phosphatidylcholine group which can be used directly.

Embodiment 2

[0034] Mix 1 part of glycerol phosphatidylcholine with 10 parts of recrystallized and purified caprolactone, dry, then add 0.01% stannous octoate catalyst based on the mass of caprolactone, mix, and dry at room temperature under a vacuum of 10 mmHg After 24 hours, vacuum seal the tube and react at 100° C. for 120 hours to obtain a biodegradable polyester (I) with a single side chain containing a phosphatidylcholine group that can be used directly.

Embodiment 3

[0036] Mix 0.01 part of glycerol phosphatidylcholine with 10 parts of recrystallized and purified lactide, dry them, and then add 5% aluminum isopropoxide catalyst based on lactide mass to mix. Dry at 100°C for 1 hour, seal the tube in vacuum and react at 180°C for 1 hour, dissolve the product in dichloromethane, precipitate out with anhydrous ether, and dry in vacuum to obtain a purified single side chain containing phosphatidylcholine group biodegradable polyester (I).

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Abstract

The present invention relates to a bio-degradable polyester containing phosphatidylcholine group, its main chain is bio-degradable polyester, the phosphatidylcholine group is positioned on the end group and side chain of polyester main chain or side chain. Its preparation method includes the following steps: (1), using glycerophosphatidylcholine to ring-open the cyclolactone so as to obtain bio-degradable polyester whose single-side chain contains phosphatidylcholine group. Said polyester can be directly used, also can be used for preparing bio-degradable polyester whose multi-side chain contains phosphatidylcholine group by adding diisocyanate and chain extender; and (2), using the above-mentioned prepared bio-degradable polyester to react with 2-chloro-2-oxy-1, 3, 2-phosphoheterocyclic pentane to obtain intermediate body, using trimethylamine to ring-open said obtained intermediate body so as to obtain the bio-degradable polyester whose end group and single-side or multi-side chain contain phosphatidylcholine group. It can be used as medicine slowly-releasing material and tissue engineering material.

Description

technical field [0001] The invention belongs to the technical field of biodegradable polymer materials and their preparation, and in particular relates to a biodegradable polyester containing phosphatidylcholine groups and a preparation method thereof. The biodegradable polyester containing phosphatidylcholine groups prepared by the present invention can be used as drug control release carrier materials, medical polymer materials and tissue engineering materials, and can also be used as coating materials for existing medical polymer materials and products. layer material. Background technique [0002] Polyesters and their copolymers are the most widely studied and used biodegradable polymers in drug controlled release and tissue engineering. However, due to the structure of polyester itself and the partial acidity generated during degradation, the expected biocompatibility cannot be obtained. Therefore, the introduction of other molecules into polyester, such as polyethyle...

Claims

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Application Information

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IPC IPC(8): C08G63/692C08G63/08C08G63/85C08K5/17C08K5/3432A61K47/34
CPCA61L27/18A61K47/34
Inventor 罗祥林王立坚罗娟周小蓓
Owner SICHUAN UNIV
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