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Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology

A topical composition, retinoid technology, applied in the direction of cosmetics, skin diseases, cosmetic preparations, etc., can solve problems such as no mention of results

Active Publication Date: 2007-02-14
PIERRE FABRE DERMO COSMETIQUE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no mention of the results obtained after in vivo application of the formulation

Method used

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  • Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology
  • Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology
  • Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Effects of topically applied hyaluronate fragments

[0045] 1. Materials and Methods

[0046] 1.1. Preparations

[0047] 3 types of hyaluronic acid fragments (HAF) were evaluated:

[0048] ·Very high molecular weight HAF (1,000,000-2,000,000Da)

[0049] ·Low molecular weight HAF (50,000-750,000Da)

[0050] -HAF (250,000-750,000Da)

[0051] -HAF (50,000-250,000Da)

[0052] ·Very low molecular weight HAF (1,000-20,000Da)

[0053] Element

Quantity in %

Quantity in %

PEG 600

5

-

PEG400

-

1

Sorbitol

-

2

Glycerin

-

10

BHT

0.02

-

sodium lauryl sulfate

-

0.25

Carbopol

1

-

vitamin E acetate

0.5

-

spermaceti

-

6

Ketostearyl Alcohol

-

3

thick petroleum jelly

5

-

Polyoxyethylene hydrogenated castor

Oil (Cremophor RH

40...

Embodiment 2

[0076] Example 2: Effect of Combination of Retinoids and Low Molecular Weight HAFs

[0077] 1. Materials and Methods

[0078] The fragments of Table 5 are included in the standard cosmetic formulations exemplified above.

[0079] fragment

Preparation 5

Preparation 6

Preparation 7

Preparation 8

HAF (250,000-750,000Da)

-

1％

-

-

HAF (50,000-250,000Da)

-

-

0.2％

-

HAF (1,000-20,000Da)

-

-

-

0.2％

Retinaldehyde (RAL)

0.05％

0.05％

0.05％

0.05％

[0080] 2. Results

[0081] They are shown in Tables 6 and 7 and in Figures 1 and 2. Topical application of Formulations 6 and 7 increased the number of sites of thickened epidermis.

[0082] preparation

Skin thickness (mm)

Dermal cell content (c / field)

Control

0.07±0.02

96±8

Preparation 5

0.17±0.02

98±4

Preparation 6

0.17±...

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Abstract

Topical composition (A), contains as active ingredient, one or more fragments (I) of hyaluronate with molecular weight 50-750 kD. ACTIVITY : Dermatological. MECHANISM OF ACTION : (I) increases the number of proliferating cells, particularly fibroblasts, in the epidermis and dermis, so induce epidermal thickening. A standard cosmetic vehicle contained 0.2 % hyaluronate fragments of molecular weight 50-250 kD and was applied twice daily to the skin of SKH1 hairless mice. After an unspecified treatment time, epidermal thickness and the number of proliferating cells were determined. The mean thickness was 0.32 mm (compare 0.07 mm in controls) and the number of cells (per microscope field) was 257 compared with 96 in controls. Also the mean number of proliferating cells (positive for the marker Ki67; per field) was 96 in the epidermis and 5 in the dermis; compare 26 and 0.95 in controls.

Description

technical field [0001] The present invention relates to hyaluronate-based topical compositions, and their use in cosmetology and dermatology. Background technique [0002] Hyaluronate (HA) is a major component of the extracellular matrix. In contrast to glycosaminoglycans such as chondroitin sulfate which are present in so-called "hard" tissues such as cartilage, it is especially present in so-called "soft" connective tissues. Thus, this substance is found to be present in significant amounts in the skin. [0003] HA is a non-sulfated linear glycosaminoglycan composed of repeating units of D-glucuronic acid and N-acetyl-D-glucosamine (Tammi R., Agren UM., Tuhkanen AL., Tammi M. Progress in Histochemistry & Hyaluronan metabolism in skin. 29(2): 1-81, 1994). [0004] In normal skin, HA is essentially synthesized by dermal fibroblasts and epidermal keratinocytes (Tammi R., already cited). Through these negatively charged residues, HA acts as a water pump, which maintains th...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q19/00A61K31/74A61K8/67A61Q19/08
CPCA61Q19/00A61K8/671A61K31/74A61K8/735A61Q19/08A61K9/0014A61K31/07A61K31/728A61P17/00
Inventor J-H·索拉特G·卡亚P·博尔达
Owner PIERRE FABRE DERMO COSMETIQUE CORP
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