Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology

A topical composition, retinoid technology, applied in the direction of cosmetics, skin diseases, cosmetic preparations, etc., can solve problems such as no mention of results

Active Publication Date: 2007-02-14
PIERRE FABRE DERMO COSMETIQUE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no mention of the results obtaine

Method used

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  • Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology
  • Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology
  • Topical composition containing hyaluronic acid fragments and retinoid useful for cosmetic and medical dermatology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Effects of topically applied hyaluronate fragments

[0045] 1. Materials and Methods

[0046] 1.1. Preparations

[0047] 3 types of hyaluronic acid fragments (HAF) were evaluated:

[0048] ·Very high molecular weight HAF (1,000,000-2,000,000Da)

[0049] ·Low molecular weight HAF (50,000-750,000Da)

[0050] -HAF (250,000-750,000Da)

[0051] -HAF (50,000-250,000Da)

[0052] ·Very low molecular weight HAF (1,000-20,000Da)

[0053] Element

Quantity in %

Quantity in %

PEG 600

5

-

PEG400

-

1

Sorbitol

-

2

Glycerin

-

10

BHT

0.02

-

sodium lauryl sulfate

-

0.25

Carbopol

1

-

vitamin E acetate

0.5

-

spermaceti

-

6

Ketostearyl Alcohol

-

3

thick petroleum jelly

5

-

Polyoxyethylene hydrogenated castor

Oil (Cremophor RH

40...

Embodiment 2

[0076] Example 2: Effect of Combination of Retinoids and Low Molecular Weight HAFs

[0077] 1. Materials and Methods

[0078] The fragments of Table 5 are included in the standard cosmetic formulations exemplified above.

[0079] fragment

Preparation 5

Preparation 6

Preparation 7

Preparation 8

HAF (250,000-750,000Da)

-

1％

-

-

HAF (50,000-250,000Da)

-

-

0.2％

-

HAF (1,000-20,000Da)

-

-

-

0.2％

Retinaldehyde (RAL)

0.05％

0.05％

0.05％

0.05％

[0080] 2. Results

[0081] They are shown in Tables 6 and 7 and in Figures 1 and 2. Topical application of Formulations 6 and 7 increased the number of sites of thickened epidermis.

[0082] preparation

Skin thickness (mm)

Dermal cell content (c / field)

Control

0.07±0.02

96±8

Preparation 5

0.17±0.02

98±4

Preparation 6

0.17±...

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Abstract

The present invention relates to topical compositions characterized in that they comprise as main constituent one or several fragments of hyaluronic acid with a molecular weight of 50,000 to 750,000 and, if desired, retinoids.

Description

technical field [0001] The present invention relates to hyaluronate-based topical compositions, and their use in cosmetology and dermatology. Background technique [0002] Hyaluronate (HA) is a major component of the extracellular matrix. In contrast to glycosaminoglycans such as chondroitin sulfate which are present in so-called "hard" tissues such as cartilage, it is especially present in so-called "soft" connective tissues. Thus, this substance is found to be present in significant amounts in the skin. [0003] HA is a non-sulfated linear glycosaminoglycan composed of repeating units of D-glucuronic acid and N-acetyl-D-glucosamine (Tammi R., Agren UM., Tuhkanen AL., Tammi M. Progress in Histochemistry & Hyaluronan metabolism in skin. 29(2): 1-81, 1994). [0004] In normal skin, HA is essentially synthesized by dermal fibroblasts and epidermal keratinocytes (Tammi R., already cited). Through these negatively charged residues, HA acts as a water pump, which maintains th...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q19/00A61K31/74A61K8/67A61Q19/08
CPCA61Q19/00A61K8/671A61K31/74A61K8/735A61Q19/08A61K9/0014A61K31/07A61K31/728A61P17/00
Inventor J-H·索拉特G·卡亚P·博尔达
Owner PIERRE FABRE DERMO COSMETIQUE CORP
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