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Multiple apertures releasing osmosis pump and preparation process thereof

一种渗透泵控释、群孔的技术，应用在渗透输送、医药配方、含有效成分的医用配制品等方向，能够解决废品率高渗透泵产品推广、生产难度大、生产周期长等问题，达到提高可靠性和稳定性、劳动强度降低、设备成本降低的效果

Active Publication Date: 2007-03-07
BEIJING KEXIN JURUN PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the design concept of the osmotic pump is very exquisite, there are too many processes in industrial production, the control indicators of each process are very strict, the production is difficult, the production cycle is long, the cost is high, and the waste rate is high, which seriously limits the promotion of osmotic pump products.

Method used

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  • Multiple apertures releasing osmosis pump and preparation process thereof
  • Multiple apertures releasing osmosis pump and preparation process thereof
  • Multiple apertures releasing osmosis pump and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Chip composition:

[0037] Venlafaxine Hydrochloride 75g

[0038] Microcrystalline Cellulose 45g

[0039] NaCl 35g

[0040] Magnesium Stearate 1g

[0041] Coating film composition:

[0042] Cellulose acetate 21g

[0043] Macrogol 6000 9g

[0044] Dibutyl sebacate 2g

[0045] Make 1000 tablets by the following preparation method:

[0046] (1) Tablet core preparation: take sodium chloride and pulverize it, cross a 100 mesh sieve, mix evenly with venlafaxine hydrochloride and microcrystalline cellulose, use ethanol as a wetting agent, make a soft material, cross a 30 mesh sieve for granulation, 45 Dry at ℃ for 2 hours, granulate, add magnesium stearate, mix well, compress into tablets, and compress 1000 tablets by conventional tablet technology.

[0047] (2) Tablet core coating: take cellulose acetate, add 600ml of acetone, stir to dissolve; take another polyethylene glycol, put it in a 50ml measuring bottle, add water to dissolve it, and then add it to the above 1...

Embodiment 2

[0050] Chip composition:

[0051] Venlafaxine Hydrochloride 75g

[0052] Alginic acid 30g

[0053] Propylene Glycol Alginate 20g

[0054] Mannitol 30g

[0055] Magnesium Stearate 2g

[0056] Coating film composition:

[0057] Polyacrylic resin 5g

[0058] Ethylcellulose 14g

[0059] Hydroxypropyl Cellulose 6g

[0060] Triethyl citrate 2g

[0061] Make 1000 tablets by the following preparation method:

[0062] (1) Tablet core preparation Take mannitol and pulverize it, pass through a 100-mesh sieve, mix evenly with venlafaxine hydrochloride, alginic acid, and propylene glycol alginate, use ethanol as a wetting agent, make a soft material, and pass through a 30-mesh sieve to granulate , dried at 45°C for 2 hours, granulated, added with magnesium stearate, mixed evenly, compressed into tablets, and compressed into 1000 tablets using conventional tablet technology.

[0063] (2) Tablet core coating: take polyacrylic acid resin, ethyl cellulose, hydroxypropyl cellulose, ad...

Embodiment 3

[0066] Chip composition:

[0067] Venlafaxine Hydrochloride 75g

[0068] Microcrystalline Cellulose 60g

[0069] Sodium chloride 40g

[0070] Magnesium stearate 0.9g

[0071] Coating film composition:

[0072] Cellulose acetate 25g

[0073] Polyethylene glycol (6000) 11g

[0074] Dibutyl sebacate 2.5g

[0075] The composition of the film coating layer containing the main drug:

[0076] Venlafaxine Hydrochloride 10g

[0077] Hypromellose 20g

[0078] Polyethylene glycol (4000) 2g

[0079] Make 1000 tablets by the following preparation method:

[0080] (1) Tablet core preparation: crush the sodium chloride and set aside. Pass 75g of venlafaxine hydrochloride, 30g of microcrystalline cellulose, and 40g of sodium chloride through a 60-mesh sieve, and mix well. Add 10% polyvinylpyrrolidone k-30 ethanol solution in an appropriate amount to make a soft material, pass through a 30-mesh sieve to granulate, and place it in an oven to heat and dry at 40°C. The prepared granu...

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PUM

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Abstract

The invention relates to a porous release penetrate pump release-control tablet and relative production. Wherein, said tablet can avoid laser holing, and it adds lots of holing agent to form continuous hole to supply release channel for the drug. The invention can simplify the production, reduce the coat and improve the safety. The invention also provides a relative alcaine porous release penetrate pump release-control tablet.

Description

technical field [0001] The invention relates to a osmotic pump controlled-release tablet released by group pores and a preparation method thereof. The group-release osmotic pump controlled-release tablet does not need laser drilling, and provides channels for drug release by adding a large amount of pore-forming agent to form continuous channels, which not only simplifies the preparation process, greatly reduces production costs, but also improves the production efficiency. Preparation safety. The invention also relates to a novel venlafaxine hydrochloride pore-release osmotic pump controlled-release tablet for treating depression. The invention belongs to the field of pharmaceutical preparations. Background technique [0002] In 1955, two Australian scholars, Rose and Nelson, invented the osmotic pump for animal drug delivery. In the 1970s, Alza Company simplified and improved the osmotic pump. In 1974, Theeuwes invented the single-chamber osmotic pump, which simplified t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K31/135A61P25/24
CPCA61K9/2853A61K9/2866A61K31/137A61K9/0004A61K31/135A61K9/2846A61K9/209A61K9/2893A61P25/22A61P25/24A61P9/10A61P9/12
Inventor 王锦刚蒋海松
Owner BEIJING KEXIN JURUN PHARM TECH CO LTD
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