Anticancer slow release agent loading both newborn blood vessel and tetrazole violet
A new blood vessel and violet technology, applied in the preparation of sustained-release preparations, sustained-release injections and sustained-release implants, can solve problems such as systemic toxicity and drug resistance limiting applications
Inactive Publication Date: 2007-03-14
SHANDONG LANJIN PHARMA
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Abstract
Disclosed is an anticancer slow release injection carrying both anti-angiogenesis agent and tetrazole Ionone, which comprises slow release micro-balloons and dissolvent, the slow release micro-balloons include anticancer active constituents, slow release auxiliary materials and specific dissolvent containing suspension agent. The anti-angiogenesis agent is selected from Marimastat, Fumagillin, gefinitib, erlotinib, lapatinib, pelinib, Thalidomide, Ranolazine, endostatin, imatinib, Avastin, sorafenib, sunitinib, the slow release auxiliary materials are selected from Polifeprosan, sebacylic acid copolymer, EVAc, polylactic acid and their mixture of copolymer, the viscosity of the suspension adjuvant is 100-3000cp (at 25-30 deg C), and is selected from sodium carboxymethylcellulose. The agent can also be prepared into implanting agent for injection or placement in or around tumor with the effects of selectively increasing local concentration, lowering general reaction of the drugs, suppressing growth of tumor cells and blood vessel, and improving the treatment effect of the non-operative treatment methods such as chemotherapy.
Application Domain
Solution deliveryPharmaceutical non-active ingredients +3
Technology Topic
Sodium carboxymethylcelluloseDepressant +27
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PUM
Property | Measurement | Unit |
Viscosity | 220.0 ~ 460.0 | cp |
Viscosity | 100.0 ~ 200.0 | cp |
Viscosity | 560.0 ~ 640.0 | cp |
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