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Medicine composition of rhodiola root and puerarin

A technology of Rhodiola rosea and a composition is applied in the field of medicine to achieve the effects of high drug purity, uniform and stable drug quality, and small quality difference

Inactive Publication Date: 2007-03-21
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the interaction of Rhodiola rosea and puerarin, there are no reports on the medicines for the treatment of cardiovascular and cerebrovascular diseases with compatible prescriptions.

Method used

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  • Medicine composition of rhodiola root and puerarin
  • Medicine composition of rhodiola root and puerarin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Example 1 Preparation of Rhodiola Rosea Extract

[0143] Take 20 kg of Rhodiola rosea medicinal material, crush it into a coarse powder, extract three times with 70% ethanol for 1 hour each time, add 10 times the amount of alcohol for the first time, and 8 and 8 times the amount for the second and third times, respectively. Filtrate, combine the extracts, recover ethanol until every 5ml contains 1g raw medicinal materials, degrease with 2 times the amount of petroleum ether, discard the petroleum ether liquid, then extract with n-butanol saturated with water, concentrate under reduced pressure to a thick paste, spray After drying, 3.07 kg of Rhodiola rosea extract was obtained, with a yield of 13.36%; the content of salidroside was 5.67%.

Embodiment 2

[0144] The refining of embodiment 2 Rhodiola rosea extract

[0145] Get the Rhodiola rosea extract 1.4kg obtained in Example 1 and dissolve it with an appropriate amount of water, add to the macroporous resin that has been treated in advance, and then use water solution, 10% ethanol, 15% ethanol, 20% ethanol, 30% ethanol Elution, the elution speed is 10ml / min. Ethanol was recovered under reduced pressure to a relative density of 1.03-1.06 (60° C.), and spray-dried to obtain 0.25 kg of rhodiola rosea extract with a yield of 2.76%; the content of salidroside was 18.43%.

Embodiment 3

[0146] Embodiment 3 Preparation of the composition powder injection of the present invention

[0147] prescription:

[0148] Puerarin 150g

[0149] Rhodiola rosea extract 27.6g (equivalent to 1000g Rhodiola rosea medicinal material)

[0150] Polysorbate 80 100g

[0151] Mannitol 400g

[0152] Add sterile water for injection to 4000ml

[0153] A total of 1000 sticks were prepared

[0154] Preparation Process:

[0155] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0156] 2) Weigh the raw materials and auxiliary materials according to the prescription quantity.

[0157] 3) Polysorbate 80 is made into a 20% aqueous solution, puerarin is added to heat and stirred to dissolve completely, and Rhodiola rosea extract is added to 20% sterile water for injection to dissolve completely. Mannitol is added with 40% sterile water for injection, heated and stirred to dissolve completely, the above solutions ar...

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparations and preparation process. The medicine composition consists of rhodiola root in 300-1800 weight portions, preferably 1000 weight portions, or its extract, and puerarin in 30-500 weight portions, preferably150 weight portions. The composition may be prepared into different pharmaceutically acceptable forms, preferably injection. The composition has synergistic effect and high stability.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a medicinal composition made of rhodiola rosea and puerarin, a preparation containing the medicinal composition and a preparation method thereof. 【Background technique】 [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, blood stasis pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the brain, which causes symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. Myocardial infarction refers to the interruption of coronary blood flow on the basis of coronary artery disease, causing severe and persistent acute ischemi...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61K31/7048A61K9/08A61P9/10A61P9/12A61P7/02
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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