Production of functional antibacterial fibre

A functional fiber and fiber technology, applied in fiber treatment, plant fiber, textile and paper making, to achieve the effect of protecting the active function of drugs

Inactive Publication Date: 2007-04-04
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There have been many studies on the inclusion of cyclodextrin drugs, but the addition of cyclodextrin to cellulose fibers to form cyclodextrin-modified fibers, and then the use of cyclodextrin attached to the fibers for drug inclusion remains to be done. research topic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A method for preparing antibacterial functional fiber, which is characterized by adopting the following steps:

[0022] A) Put the cellulose fiber into a 0.1% NaOH solution to swell for 3 hours at a weight ratio of 1:20;

[0023] B) Put the swollen cellulose fibers into an aqueous solution containing 8% epichlorohydrin and 5% NaOH at a weight ratio of 1:50, and react at 80°C for 2 hours to obtain epoxidized cellulose fibers. Then take it out and wash it;

[0024] C) Put the epoxidized cellulose fiber into a 30% sodium hydroxide solution at a weight ratio of 1:50, and then add 90% cyclodextrin by weight of the epoxidized cellulose fiber, at 30°C Carry out polymerization reaction for 5 hours to obtain cellulose-cyclodextrin polymer fiber;

[0025] D) Put the cellulose-cyclodextrin fiber polymer into a chloramphenicol solution with a concentration of 10% in a weight ratio of 1:10, and carry out the inclusion reaction at 10°C for 15 hours to form a chloramphenicol inclusion Cel...

Embodiment 2

[0029] A method for preparing antibacterial functional fiber, which is characterized by adopting the following steps:

[0030] A) Put the cellulose fiber into a 0.1% NaOH solution to swell for 0.5 hours at a weight ratio of 1:50;

[0031] B) Put the swollen cellulose fibers into an aqueous solution containing 8% epichlorohydrin and 5% NaOH in a weight ratio of 1:100, and react at 30°C for 5 hours to obtain epoxidized cellulose fibers. Then take it out and wash it;

[0032] C) Put the epoxidized cellulose fiber into a 30% sodium hydroxide solution at a weight ratio of 1:100, and then add 20% cyclodextrin by weight of the epoxidized cellulose fiber at 60°C Carry out polymerization reaction for 1 hour to obtain cellulose-cyclodextrin polymer fiber;

[0033] D) Put the cellulose-cyclodextrin fiber polymer into a chloramphenicol solution with a concentration of 1% at a weight ratio of 1:100, and carry out the inclusion reaction at 60°C for 5 hours to form a clathrate containing chloram...

Embodiment 3

[0037] A method for preparing antibacterial functional fiber, which is characterized by adopting the following steps:

[0038] A) Put the cellulose fiber in a 0.1% NaOH solution to swell for 2 hours at a weight ratio of 1:35;

[0039] B) Put the swollen cellulose fibers into an aqueous solution containing 8% epichlorohydrin and 5% NaOH at a weight ratio of 1:70, and react at 50°C for 4 hours to obtain epoxidized cellulose fibers. Then take it out and wash it;

[0040] C) Put the epoxidized cellulose fiber into a 30% sodium hydroxide solution at a weight ratio of 1:70, and then add 60% cyclodextrin by weight of the epoxidized cellulose fiber at 40°C Carry out polymerization reaction for 3 hours to obtain cellulose-cyclodextrin polymer fiber;

[0041] D) Put the cellulose-cyclodextrin fiber polymer into a 6% chloramphenicol solution at a weight ratio of 1:50, and carry out the inclusion reaction at 40°C for 8 hours to form a chloramphenicol inclusion Cellulose-cyclodextrin fiber pol...

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PUM

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Abstract

It is a method of preparing functional antibacterial fiber. Its character lies in that CD grafted to cellulose fiber to Form cyclodextrin-cellulose fiber polymer including chloramphenicol serving to be antibacterial. Compared with the existing technology, the invention of the advantages are : a) the CD received cellulose fiber, CD Modified fiber formation, and then use the fiber of cyclodextrin inclusion drugs, achieving CD - cellulose polymer drug screening, controlled drug release, the protection function of drug activity; 2) Antibiotics can be functional fiber weaving, tailoring, made of various kinds of medicinal materials functional textiles, Surgical dressing for antibacterial materials, wartime emergency bandaging materials, and better meet the medical needs of a different.

Description

Technical field [0001] The invention relates to a cyclodextrin and its derivatives, in particular to a method for preparing an antibacterial functional fiber. Background technique [0002] Chloramphenicol is a broad-spectrum antibiotic that has a broad-spectrum antimicrobial effect in vitro, including aerobic gram-negative bacteria and gram-positive bacteria, anaerobes, rickettsia, spirochetes and chlamydia. It has a bactericidal effect against influenza bacillus, streptococcus pneumoniae and Neisseria meningitidis; against Staphylococcus aureus, Streptococcus pyogenes, Streptococcus viridis, Group B hemolytic streptococcus, Escherichia coli, Klebsiella pneumoniae, Strange Proteus, Salmonella typhi, Salmonella paratyphi, Shigella, Bacteroides fragilis and other anaerobic bacteria have antibacterial effects. Chloramphenicol has corresponding applications in surgical diseases, and has good effects, such as treating infectious wounds, burn infections, etc.; it has antibacterial and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/03D06M13/11D06M13/402D06M101/06
Inventor 胡智文万军民陈锐彬陈文兴
Owner ZHEJIANG SCI-TECH UNIV
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