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Red sage root effective part standard extract and its preparing method and use

A technology for effective parts and extracts, which is applied to the standard extract of effective parts of Salvia miltiorrhiza and its preparation and application fields, and achieves the effects of good safety, good protection effect, and ingenious and reasonable process combination.

Inactive Publication Date: 2007-04-11
北京宝泰宁堂生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above situation shows that due to technical reasons, there has not been a preparation technology and product that can truly represent all the active ingredients of Danshen, as well as a quality standard that can truly control the internal quality of the product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: Extract the method of salvia miltiorrhiza effective component (tanshinolone) from raw material salvia miltiorrhiza

[0032] The salvia miltiorrhiza medicinal material used in the method of the present invention is purchased from the market or the production base of salvia miltiorrhiza GAP, and the equipment used is the extraction and processing equipment commonly used in the field of traditional Chinese medicine pharmacy. The carbon dioxide supercritical extraction device can be self-made, or the finished product can be purchased from the market.

[0033] The method for extracting tanshinolones of the present invention comprises: extracting tanshinone compounds with carbon dioxide supercritical extraction technology, decocting with water to extract water-soluble salvianolic acids and purifying them with ethyl acetate. This process greatly improves the transfer rate of the two types of components in the standard extract and its preparations compared with the...

Embodiment 2

[0046] The preparation of the tablet that embodiment 2 contains tanshinolone

[0047] Take 100g of tanshinolone, 50g of pregelatinized starch, and 26.4g of sodium carboxymethyl starch, pass through a 60-mesh sieve and mix until uniform, add an appropriate amount of absolute ethanol to make a soft material, granulate with a 18-mesh sieve, dry at 40°C, and mix through a 18-mesh sieve After granulation, add 17.6 g of sodium carboxymethyl starch and 2 g of magnesium stearate, mix evenly, and compress into 1000 tablets to obtain tablet cores (plain tablets), which are coated with 8% film-coating premix ethanol solution in a sugar-coating pan. Coating is to get tanshinolone film-coated tablets, weighing 250 mg, containing 100 mg tanshinolone.

Embodiment 3

[0048] Composition determination and quality control of embodiment 3 tanshinolone and tanshinolone tablet

[0049] In order to effectively control the quality, we analyzed the extracted product tanshinolone and tanshinolone tablets. Taking total salvianolic acid, salvianolic acid B, total tanshinone, and tanshinone II A as the main quantitative quality control indicators, the above components were determined by UV and HPLC methods, and the quality inspection indicators were formulated according to the specific test results, as shown in Table 1.

[0050] Tanshinone

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Abstract

The invention relates to extracting tanshinpropanone from the effective part of the root of red-rooted salvia and preparation thereof and application of medicinal compound from said extracting stuff in preparation of drugs for treatment and prevention for blood shortage disease of heart and brain. Process for tanshinpropanone is as follows, extracting tanshinone type compound by supercritical extracting technique of carbon dioxide, boiling with water and extracting soluble salvianolic acid type and purifying thereof through ethyl acetate, thereafter mixing these two solid powder obtained according to extracting rate and content converting.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine preparation and its preparation method and application; more specifically, the present invention relates to a standard extract of salvia miltiorrhiza tanshinolone, its preparation method and a pharmaceutical composition comprising the standard extract of salvia miltiorrhiza tanshinolone and its application in the preparation of medicines for treating cardio-cerebral ischemic diseases. Background technique [0002] Salvia miltiorrhiza, the raw material used in tanshinolone, is a traditional traditional Chinese medicine, which is recorded in the previous editions of the Pharmacopoeia of the People's Republic of China. Relevant teaching materials, monographs and dictionaries of Chinese medicine colleges and universities are included as key drugs for introduction. Salvia miltiorrhiza is the root of Salvia miltiorrhiza Bge. For a long time, Danshen has been widely used in the treatment of vari...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/10A61P9/00
Inventor 廖幼鸣邓文龙萧效良
Owner 北京宝泰宁堂生物技术有限公司
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