Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms

A sustained-release, oral dosing technology, applied in pharmaceutical formulation, pill delivery, drug combination, etc., can solve problems such as respiratory weakness, opioid drug overdose, death, etc.
CN1957909AActive Publication Date: 2007-05-09ALZA CORP
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ALZA CORP
Publication Date
2007-05-09

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Abstract

Disclosed are methods of sustained release administration of opioids, including but not limited to hydromorphone and oxycodone, that exhibit improved properties with respect to co-ingestion with aqueous alcohol.
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Description

technical field

[0001] The present invention relates to methods of sustained release administration of opioids, including but not limited to hydromorphone and oxycodone, which exhibit improved properties when administered in combination with aqueous alcoholic solutions. Background technique

[0002] Ethanol-Induced Opioid Sustained Release Dose burst release from oral dosage forms is a serious problem for patients taking such oral dosage forms.

[0003] Opioid sustained release oral dosage forms are designed to deliver an opioid to a patient over an extended period of time. Often a single dose of an opioid sustained release oral dosage form is used instead of multiple doses of an opioid immediate release oral dosage form. For example, there is a great need for once-daily (qd) and twice-daily (bid) administration of sustained-release oral dosage forms of opioids to relieve patient suffering throughout the day.

[0004] Thus, such dosage forms, especially once-daily sustaine...

Claims

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