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Modified montmorillonite, preparation method and application

A montmorillonite and modified technology, used in pharmaceutical formulations, active ingredients of aluminum/calcium/magnesium, drug delivery, etc., can solve the problem of no treatment for chronic atrophic gastritis reversal, no treatment for chronic atrophic gastritis. And other issues

Inactive Publication Date: 2007-05-09
ZHEJIANG HAILISHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no treatment that can effectively block chronic atrophic gastritis, let alone a treatment that can reverse chronic atrophic gastritis.

Method used

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  • Modified montmorillonite, preparation method and application
  • Modified montmorillonite, preparation method and application
  • Modified montmorillonite, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Embodiment 1 Preparation of modified montmorillonite

[0148] The phase analysis of purified montmorillonite is shown in Figure 1.

[0149] In the purification of montmorillonite, add a mixed acid with a concentration of 2mol / L, the composition of the mixed acid is (the molar ratio of hydrochloric acid: oxalic acid: acetic acid is 4:10:6), and the mass ratio of soil: acid is 1:3. Mix, boil at 100°C for 5-6 hours, filter to remove the mixed acid, wash the filter cake with deionized water to pH ≥ 4, dry at 100°C, and grind it into 300-500 mesh to obtain the modified calcium base For montmorillonite, see Figure 2 for its abundance or phase analysis.

[0150] Prepare the obtained modified calcium-based montmorillonite with 0.5N hydrochloric acid solution to make a slurry with a solid content of 20%, stir for 6 hours, filter to remove the acid solution, wash the filter cake with hot water at 60°C until the pH is about 5, press Filter into a filter cake with a solid content o...

Embodiment 2

[0151] Example 2 Preparation of modified montmorillonite

[0152] The phase analysis of purified montmorillonite is shown in Figure 4.

[0153] In the purification of montmorillonite, add a mixed acid with a concentration of 1mol / L, the composition of the mixed acid is (the molar ratio of hydrochloric acid: oxalic acid: acetic acid is 3:4:3), and the mass ratio of soil: acid is 1:4. Mix, boil at 90°C for 6-8 hours, filter to remove the mixed acid, wash the filter cake with deionized water to pH ≥ 4, dry at 120°C, and grind it into 300-500 mesh to obtain the modified calcium base For montmorillonite, see Figure 5 for its abundance or phase analysis.

[0154] The obtained modified calcium-based montmorillonite was mixed with 0.5N sulfuric acid solution to make a slurry with a solid content of 15%, stirred for 6 hours, filtered to remove the acid solution, and the filter cake was washed with hot water at 70°C until the pH was about 5.5. Pressure filtration into a filter cake wi...

Embodiment 3

[0155] Example 3 Preparation of modified montmorillonite

[0156] Mineral composition of raw bentonite: see Figure 8.

[0157] The raw ore is dried, crushed, passed through a 50-mesh sieve, added water and 0.3% sodium hexametaphosphate of raw ore powder to form a slurry with a solid content of 20%, stirred for two hours, passed through a three-stage hydrocyclone, and separated The slurry is mixed with water to make a thin slurry with a solid content of 3%, which is separated in a disc centrifuge, and the separated thin slurry is concentrated in another disc centrifuge, and the concentrated slurry is passed through a plate and frame filter press After pressure filtration, a filter cake with a solid content of 40-50% was obtained. The filter cake was dried at 125° C. and crushed to a size above 500 mesh. The mineral composition of the purified montmorillonite is shown in FIG. 8 .

[0158] In the purification of montmorillonite, add a mixed acid with a concentration of 2mol / L (t...

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Abstract

A modified montmorillonite with exposed and increased electric charges on its end face and between layers, lower ordered structure in C axis and improved curative effect for the reversible therapy of chronic atrophic gastritis is disclosed. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an inorganic medicine, in particular to a modified montmorillonite, a modified sodium-based montmorillonite, a preparation method thereof and an application thereof. Background technique [0002] Chronic atrophic gastritis (CAG) is a common and stubborn digestive system disease, the incidence rate in the general population can reach 7.5-13.8%, and there are about 150 million chronic atrophic gastritis in China patient. CAG is also recognized as a precancerous lesion of the stomach, and its cancer rate is as high as about 10%, especially significantly related to the incidence of intestinal type gastric cancer. prevention. [0003] The etiology of CAG is complex, and Helicobacter pylori (H.pylori), bile, alcoholism and non-steroidal anti-inflammatory drugs are common pathogenic factors. Chinese medicine classifies CAG into the categories of "epigastric pain", "noisy" and "fullness". It is usually divided into three types: sple...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/00A61P1/04A61P1/16A61P5/16A61P25/32C01B33/26
Inventor 吕光烈郑海辉胡秀荣夏志国陈绩馨
Owner ZHEJIANG HAILISHENG PHARM CO LTD
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