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Medication eluting type blood vessel bracket

A vascular stent and drug technology, applied in the field of vascular stents, can solve the problems of easy detachment and restenosis polymer layer, and achieve the effect of not easily detached

Inactive Publication Date: 2007-05-09
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the drug-eluting vascular stent is implanted, the functional drug is released to exert highly effective anti-platelet and anti-coagulant effects at the implantation site, so as to overcome the restenosis and subacute thrombosis and the easy shedding of the polymer layer in the prior art. question

Method used

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  • Medication eluting type blood vessel bracket
  • Medication eluting type blood vessel bracket
  • Medication eluting type blood vessel bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation steps of a kind of hirudin-eluting vascular stent are as follows:

[0034] (1) Preparation of butyl titanate solution

[0035] The butyl titanate solution is prepared according to the following substances and molar concentration ratios, butyl titanate: ethylene glycol methyl ether: ethyl acetoacetate: water = 0.5: 10: 0.5: 1, first add titanium to ethylene glycol methyl ether butyl ester, mix well and then add ethyl acetoacetate and water;

[0036] (2) Place the vascular stent in butyl titanate solution for processing

[0037] Soak the vascular stent in butyl titanate solution for 5 minutes, take it out and dry it at room temperature, then place it in a muffle furnace for heat treatment at 600°C, the heating rate is 8°C / min, keep it warm for 5 hours, take it out and dry it at room temperature cooling the vascular stent to form a titanium dioxide layer with a surface roughness of 0.5 μm on the surface of the vascular stent;

[0038] (3) Preparation of ...

Embodiment 2

[0044] The preparation steps of an anti-platelet monoclonal antibody eluting vascular stent are as follows:

[0045] (1) Preparation of butyl titanate solution

[0046] The butyl titanate solution is prepared according to the following substances and molar concentration ratios, butyl titanate: ethylene glycol methyl ether: ethyl acetoacetate: water = 3: 30: 3: 10, first add titanium to ethylene glycol methyl ether Butyl acetoacetate, mix well and then add ethyl acetoacetate and water;

[0047] (2) Place the vascular stent in butyl titanate solution for processing

[0048] Soak the vascular stent in butyl titanate solution for 5 minutes, take it out, dry it at room temperature, and then place it in a muffle furnace for heat treatment at 450°C at a heating rate of 4°C / min, keep it warm for 0.5 hours, take out the stent, A titanium dioxide layer with a surface roughness of 0.1 μm is formed on the surface of the vascular stent;

[0049] (3) Preparation of polymer solution

[0...

Embodiment 3

[0055] The preparation steps of a kind of protamine eluting vascular stent are as follows:

[0056] (1) Preparation of butyl titanate solution

[0057] The butyl titanate solution is prepared according to the following substances and molar concentration ratios, butyl titanate: ethylene glycol methyl ether: ethyl acetoacetate: water = 2: 20: 2: 5, first add titanium to ethylene glycol methyl ether Butyl acetoacetate, mix well and then add ethyl acetoacetate and water;

[0058] (2) Place the vascular stent in butyl titanate solution for processing

[0059] Soak the vascular stent in butyl titanate solution for 20 minutes, take it out and dry it at room temperature, then place it in a muffle furnace for heat treatment at 550°C at a heating rate of 6°C / min, keep it warm for 3 hours, take it out and dry it at room temperature cooling the vascular stent to form a titanium dioxide layer with a surface roughness of 0.3 μm on the surface of the vascular stent;

[0060] (3) Preparati...

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Abstract

A medicine eluted scaffold of blood vessel is composed of a scaffold body, a TiO2 layer and a surficial medicine-polymer layer. Its preparing process includes such steps as roughening the surface of scaffold body, preparing a TiO2 layer on the roughened surface, coating a polymer layer, and combing medicine with said polymer layer.

Description

[0001] This application is a divisional application. The filing date of the original application is August 13, 2004. The application number is 200410040450X. The title of the invention is: preparation method of drug-eluting vascular stent and drug-eluting vascular stent technical field [0002] The invention relates to a vascular stent, in particular to a drug-eluting vascular stent capable of releasing therapeutic drugs. The drug-eluting blood vessel stent can effectively prevent restenosis and thrombosis after stent implantation. Background technique [0003] In 1969, under fluoroscopy, Dotter placed a self-made stainless steel densely threaded vascular stent in the surrounding blood vessels of dogs. This stent maintained the patency of the blood vessels for two and a half years. He proved for the first time that the stainless steel vascular stent can be integrated with the vessel wall [DotlerCT . Transluminally placed coil springs and arterial tube graffs. Long-tern paten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/12A61F2/82
Inventor 王贵学尹铁英阮长耿罗贝尔·吉杜安沈阳
Owner CHONGQING UNIV