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Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof

A nanofiber membrane and biodegradation technology, applied in the field of gelatin-based nanofiber membrane materials and their preparation, can solve the problems of limiting the wide application of gelatin, difficult to completely remove residual organic solvent, and thick diameter.

Inactive Publication Date: 2010-04-21
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, several documents and patents about gelatin dry or wet spinning have been reported, but the gelatin and gelatin-based composite fibers prepared by the prior art generally have a relatively thick diameter (greater than 10 microns), which is limited. The further wide application of gelatin in the field of biomedicine
Electrospinning method is an effective means to prepare ultrafine fibers, but because the aqueous solution of pure gelatin is in a colloidal state at room temperature, and because gelatin is not easily soluble in general organic solvents, it is difficult to perform electrospinning on gelatin. There are only a few reports on the electrospinning of gelatin in some organic fluorinated solvents (Polymer, 2004, 45: 5361-5368; J.Biomed.Mater.Res., 2005, 72B, 156-165; Polymer, 2005 , 46, 5094~5120.), but this method has problems such as expensive solvents, high toxicity of organic solvents, difficulty in completely removing residual organic solvents, and difficulty in solvent recovery, which limits the further application of gelatin nanofibers

Method used

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  • Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof
  • Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof
  • Nano copolymer fibrous membrane material capable of being biodegraded and absorbed and preparation process and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1) Prepare 50 ml of water / ethanol solution of gelatin with a mass volume concentration of 15w / v%, wherein the gelatin is medicinal gelatin with a molecular weight of 80,000, and the volume ratio of water / ethanol is 90:10, and put it in a solution device;

[0045] 2) The spinneret is fixed, the metal plate is used as a collector, and the collector moves horizontally at a moving speed of 0.3m / s and a moving range of 10cm;

[0046] 3) adjust the distance between the spinneret and the collecting plate to be 15cm;

[0047] 4) The ambient temperature of spinning is 45 degrees, including the temperature of the solution in the liquid storage device and the temperature of the collecting plate are both 40 degrees, and the air flow rate in the environment is controlled at 0.5 ~ 0.8m 3 / hr;

[0048] 5) Turn on the high-voltage power supply, adjust the voltage to 22KV, and the feeding speed of the solution is 60ul / min, and perform spinning. The average fiber diameter is 200nm, and...

Embodiment 2

[0051] 1) Prepare 20ml of water / ethanol solution of gelatin / hyaluronic acid with a gelatin concentration of 4.5w / v%, wherein the mass ratio of gelatin / hyaluronic acid is 4:1, and the volume ratio of water / ethanol is 90:10. The substance solution is placed in the liquid storage device;

[0052] 2) The spinneret moves horizontally at a speed of 0.5m / min. The metal plate acts as a collector, and the collector moves horizontally with a moving speed of 1m / min and a moving range of 10cm;

[0053] 3) adjust the distance between the spinneret and the collecting plate to be 20cm;

[0054] 4) The ambient temperature of spinning is 45 degrees, including the temperature of the solution in the liquid storage device and the temperature of the collecting plate are 45 degrees, and the air flow velocity in the environment is 1m 3 / hr;

[0055] 5) Turn on the high-voltage power supply, adjust the voltage to 25KV, and the feeding speed of the solution is 100ul / min, and perform spinning, and th...

Embodiment 3

[0058]1) Prepare 100ml of water / ethanol solution of gelatin with a mass volume concentration of 10w / v%, wherein the volume ratio of water / ethanol is 90:10, add 2 mg of nano-silver to the gelatin aqueous solution, mix well and place in the stock solution device;

[0059] 2) The metal copper mesh is used as a collector, and the spinneret and the receiver are fixed;

[0060] 3) adjust the distance between the spinneret and the collecting plate to be 15cm;

[0061] 4) The ambient temperature of spinning is 45 degrees, including the temperature of the solution in the liquid storage device and the temperature of the collecting plate are 45 degrees, and the air velocity in the environment is 2m 3 / hr;

[0062] 5) Turn on the high-voltage power supply, adjust the voltage to 25KV, and spin the solution at a feeding rate of 80ul / min. The obtained fiber film is vacuum-dried at 40 degrees for 2 days; the average fiber diameter is 300nm, and the film thickness is 1cm;

[0063] 6) Soak t...

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Abstract

The invention relates to a gelatin nanometer fiber film which can biologically degrade and absorb, and relative preparation, wherein it via the control on static spin realizes the static spin on gelatin water solution and gelatin / macromolecule mixture water, to obtain the nanometer fiber, which comprises: 0<gelatin<100deals, macromolecule at 0-100deals, treatment drug at 0-10deals, inorganic strengthener at 0-50deals; the fiber diameter is 3-10000nm, and its crosslink degree is 0-100%. The invention has better compatibility and absorption property. It can be used in drug release film, etc.

Description

technical field [0001] The invention belongs to the field of biodegradable and bioabsorbable polymer non-woven fabric materials, in particular to a biodegradable and bioabsorbable gelatin-based nanofiber membrane material and its preparation method and application. Background technique [0002] Electrospinning is a simple and effective process for preparing polymer ultrafine fibers. The principle of this method is that the polymer fluid is charged with thousands to tens of thousands of volts of high-voltage static electricity, and the charged polymer droplets form a Taylor cone under the action of the electric field force, and are accelerated at the apex of the cone. When the electric field is strong enough , the polymer droplets overcome the surface tension to form a jet stream, which forms various forms of unstable flow in the air and finally falls on the grounded receiving device. According to the different receiving devices, it can form a non-woven fabric or A polymer f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/14A61K45/00D01D5/00D01F1/00A61L27/60A61L33/06A61L24/04A61L15/22A61F2/02
Inventor 韩志超贺爱华李军星
Owner INST OF CHEM CHINESE ACAD OF SCI
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